Using Nitroglycerin To Treat Prostate Cancer Shows Potential To Halt Disease



由 - 20102378年2月12日
利用硝酸甘油和类似化合物治疗癌症的研究。亚当斯、格雷厄姆和希顿已经在全球范围内获得了10项专利。皇后大学的技术转让办公室PARTEQ创新公司已经将部分知识产权授权给了Nometics Inc.,这是一家名为Nometics Inc.的公司,该公司正在研发基于此和相关研究的产品和治疗方法。
“这项经过同行评审的研究是我们第一次明确的临床证据,证明低剂量的一氧化氮疗法为前列腺癌患者提供了一种新的非侵入性治疗方案,”Nometics的首席执行官罗伯特·本德(Robert Bender)说。“我们打算在2010年开展更广泛的临床试验,以证实和扩大这些结果。”



By - February 12, 20102378

Treatment of prostate cancer using a very low dose of nitroglycerin may slow and even halt the progression of the disease without the severe side effects of current treatments, Queen’s University researchers have discovered. The findings are the result of the first-ever clinical trial using nitroglycerin to treat prostate cancer. The 24-month, Phase II study targeted 29 men with increasing levels of prostate-specific antigen (PSA) following prostate surgery or radiation. PSA levels are a key predictor of cancer progression.


We were very excited to see a significant slowing in the progression of the disease as evidenced by the men’s PSA levels, and to see this result in many of the men who completed the study,” says Robert Siemens, the leader of the study and a Professor of Urology at Queen’s University and urologist at Kingston General Hospital.


The researchers are encouraged by the results, particularly because safe and effective treatments for men with rising PSA levels following surgery or radiation are limited. They note that further testing needs to be done to confirm the results of this very small study.


The men were treated with a low-dose, slow-release nitroglycerin skin patch and their PSA levels monitored. Of the 17 patients who completed the study, all but one showed a stabilization or decrease in the rate of cancer progression, as measured by their PSA Doubling Time.


Nitroglycerin has been used at significantly higher doses for more than a century to treat angina. This trial was based on a key finding from pre-clinical research carried out at Queen’s, which showed that decreases in nitric oxide play an important role in tumor progression and that this progression can be stopped by low-dose nitroglycerin.


Prostate cancer is diagnosed in approximately 235,000 men per year in the United States and 20,700 in Canada. Of patients who have undergone radical prostatectomy and/or radiation treatment, it is estimated that 30 to 50 percent will experience a recurrence of cancer.


Results of the study, conducted by Queen’s University researchers Robert Siemens, Jeremy Heaton, Michael Adams, Jun Kawakami and Charles Graham, appeared in a recent issue of the journal Urology.


Research into the use of nitroglycerin and similar compounds for the treatment of cancer by Drs. Adams, Graham and Heaton has resulted in the issue of 10 patents worldwide. PARTEQ Innovations, the technology transfer office of Queen’s, has licensed some of this intellectual property to Nometics Inc., a Queen’s spinoff company, which is developing products and therapies based on this and related research.


This peer-reviewed research is our first clear clinical evidence that low-dose nitric oxide therapy offers prostate cancer patients a new non-invasive treatment option,” says Robert Bender, CEO of Nometics. “It is our intention to start broader clinical trials in 2010 to confirm and expand these results.”


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Adapted from materials provided by Queen’s University, via EurekAlert!, a service of AAAS.

Using Nitroglycerin To Treat Prostate Cancer Shows Potential To Halt Disease | Nutrition Review