Dehydroascorbic Acid (DHAA) - A Vital Natural Form Of Vitamin C And Better Than Ascorbic Acid In Many Metabolic Processes
案例研究1 - DHAA和类癌症状 63岁的女性在2010年被诊断患有类癌。原发肿瘤切除部分小肠。广泛的肝转移这种疾病还会导致快速的转运消化和微量营养素的吸收不良。 她的皮肤形状非常糟糕，非常薄而且易碎，容易擦伤或撕裂，受伤后长达一周的瘀伤会扩散，多产的皮肤脱落明显，切口和瘀伤愈合很慢。 虽然它似乎是一种微量营养素问题，但由于类癌综合症，她无法服用口服维生素C或烟酸，因此她试用了局部应用的DHAA血清。由于怀疑维生素缺乏，她还用它作为漱口水和漱口，因为她的牙龈和牙齿松动。 结果令人震惊，不久她的朋友和我的朋友，加上我的工作人员要求一些，他们经常用它作为一线治疗或补充处方药，几乎任何影响皮肤，口腔或喉咙的东西。它甚至已成功用于痔疮局部 。
脱氢抗坏血酸（DHAA)如何发挥作用研究表明，与局部抗坏血酸血清相比，DHAA在深层皮肤细胞中的提供高达12倍的维生素C细胞间水平.摄取增加的主要原因是通过皮肤的更好穿透和通过细胞壁中的不同受体进入细胞的DHAA摄取。抗坏血酸使用SVCT受体（维生素C钠转运蛋白），这种途径通过关闭约220μmol/ L的水平来限制吸收。脱氢抗坏血酸使用约500μmol/ L的GLUT受体。这意味着通过局部使用DHAA可以通过服用或局部使用纯抗坏血酸来增加皮肤中的抗坏血酸水平。 DHAA与抗坏血酸相同，只是缺少两个氢离子。一旦DHAA通过皮肤保护层，它就会通过GLUT受体被吸收到细胞中，一种名为谷胱甘肽的天然抗氧化剂补充了两个缺失的氢离子，从而将分子转变为纯抗坏血酸，并为细胞提供抗氧化保护。 由此引起的谷胱甘肽的消耗很快被免疫系统纠正，并且约一小时后在相同的细胞中产生新的谷胱甘肽。 值得注意的是，有趣的是，不仅仅是替换使用的谷胱甘肽的量，而是产生了显着的过剩，因此皮下细胞最终会被加入非常高剂量的抗坏血酸和增强的谷胱甘肽水平。免疫系统 被重新充电！还值得注意的是，低谷胱甘肽水平与衰老的影响有关。
Here at Vitamin Solutions we manufacture a powerful form of vitamin C that has been scientifically shown to have the ability to penetrate through skin 12 times more effectively than pure ascorbic acid (pure vitamin C).
This website uses case studies to show the results from the topical application of Dehydroascorbic Acid (DHAA) vitamin C serum to several persistant skin issues including thin easily torn and bruised skin, skin tears, infections, basal cell carcinomas, actinic keratoses, treatment resistant fungal skin and nail infections, flaking skin, side effects of some cancers and wound healing.
Skin and blood vessels use collagen as the lattice material to hold cells together, repair damage, form scars, prevent leakage and protect from infection. Vitamin C is necessary for the formation of collagen and for the immune system to be able to fight infection.
In areas of low blood flow and/or at times of very high demand for additional vitamin C due to infections, cuts, burns or illness the vitamin C level in skin can become depleted and it's here where the Dehydroascorbic Acid form of vitamin C can make a huge difference.
What Is Dehydroascorbic Acid (DHAA)
Pure vitamin C comes in two natural forms in fruits and vegetables. The reduced form is the vitamin C we all know from supplements (it is actually Ascorbic Acid). The other form is Dehydroascorbic Acid.
Both molecules are antioxidants but the Dehydroascorbic Acid (DHAA) is far better able to penetrate the skin and has more powerful anti-viral and anti-fungal properties, it is also the main form that transports vitamin C around the body.
DHAA has many important roles in the body and is the only form of vitamin C capable of crossing the blood/brain barrier. DHAA is vital for many other cellular processes. Having both DHAA and Ascorbic Acid together mimics nature best.
In some vegetables (swiss chards) all the vitamin C is often in the form of DHAA, while the vitamin C rich persimmon often has a 50/50 mix of both types. Usually vitamin C levels in fruits and vegetables given on dietary charts is calculated as follows - Ascorbic Acid plus DHAA = total vitamin C.
Dehydroascorbic Acid (DHAA) - The Science and Case Studies
Douglas Kitt is an expert in the field of the DHAA form of Vitamin C and it's extraordinary properties, he has written several scientific papers including the one below.
Topical Dehydroascorbic Acid (Oxidized Vitamin C) Permeates Stratum Corneum More Rapidly Than Ascorbic Acid.
The results show that the DHAA form of vitamin C permeates skin at a rate up to 12 times faster than Ascorbic Acid (normal vitamin C).
Case Study 1 - DHAA and Carcinoid Cancer Symptoms
63 year old female diagnosed in 2010 with carcinoid cancer. Primary tumor removed with part of her small intestine. Extensive liver metastasis This illness also causes rapid transit digestion and malabsorption of micro-nutrients.
Her skin was in very bad shape, it was very thin and fragile, easily bruised or torn, bruises would spread for up to a week after injury, prolific skin shedding was evident and cuts and bruises were very slow to heal.
While it appeared to be a micro nutrient issue she was unable to take oral Vitamin C or niacin due to carcinoid syndrome so she tried DHAA serum applied topically. She also used it as a mouthwash and gargle for her weak gums and loose teeth due to the suspected vitamin deficiency.
The results were astounding, before long her friends and mine, plus my staff were asking for some, they often used it as a first line treatment or complementary to prescription medicine for just about anything affecting the skin, inside the mouth or throat. It has even been successfully used topically on hemorrhoids. Click on the links in the menu to read some of their their stories.
Prior to this, increasing Vitamin C levels to alleviate whole body scurvy like symptoms through applying topical DHAA and ascorbic acid was unheard of. Read her case study here
DHAA Ascorbic Acid Serum has equally potent effects on infections and burns. The Ascorbic Acid in the serum will penetrate directly into areas where the skin is broken or missing and the DHAA component will penetrate quickly into the surrounding unbroken skin. Read the reports and dosages of DHAA Ascorbic Acid serum here
How Does Dehydroascorbic Acid Work
Research shows DHAA delivers up to twelve times more Vitamin C at an inter cellular level in deep skin cells than topical ascorbic acid serums. The main reasons for the increased uptake is better penetration through the skin and DHAA uptake entering cells through different receptors in the cell wall. Ascorbic Acid uses SVCT receptors (sodium vitamin C transporters) and this path limits absorption by shutting down at a level of around 220 µmol/L. Dehydroascorbic Acid uses GLUT receptors that shut down at around 500 µmol/L. This means you can increase ascorbic acid levels in skin much higher by applying DHAA topically than you can by taking or topically applying pure ascorbic acid.
DHAA is the same as Ascorbic Acid except that two hydrogen ions are missing. As soon as DHAA has passed through the protective layer of skin it is absorbed into the cells through GLUT receptors and a natural antioxidant called glutathione replaces the two missing hydrogen ions, thus turning the molecule back into pure Ascorbic Acid and giving the cell antioxidant protection.
The depletion of glutathione caused by this is soon corrected by the immune system and after about a hour new glutathione is produced in those same cells.
The really interesting thing to note is that instead of just replacing the amount of glutathione used, a significant surplus is made so the subcutaneous cells wind up being charged with a very high dose of ascorbic acid plus enhanced glutathione levels. The immune system is supercharged! It is also noteworthy that low glutathione levels are associated with the effects of aging.
Full Article: The physiological role of dehydroascorbic acid
Another informative research paper below also discusses this effect.
Abstract: Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C
DHAA Vitamin C Serum - Our Observations
On infected areas the combination of Ascorbic Acid, DHAA and Glutathione act together rapidly reducing swelling and pain. We have observed several worsening infections undergo a complete turnaround in a matter of hours after applying our DHAA/Ascorbic Acid Serum.
DHAA and Vitamin C appears to help wounds heal much faster. After around six weeks it noticeably rebuilds collagen and elastin integrity and strengthens blood vessels, capillary leakage is noticeably reduced. It may also improve the flow of oxygen and nutrients to the wound and enhance the lymph gland and the vascular endothelial system as swelling reduces soon after treatment begins. These actions give better protection against future leakage and swelling and improve the chances of reducing and overcoming infections.
Aged Skin With Degenerated Blood Vesselsl
In an 89 year old female treated with DHAA Vitamin C serum for a badly infected toenail which had not responded to two courses of antibiotics we found a secondary condition common among the aged. She had poor capillary integrity on the shins of both legs and scurvy like skin lesions.
The skin was thin and fragile and bruising would result from the slightest knock. She was on blood thinners which would likely make the condition worse or may perhaps even be the cause. Deep bruising would occur in response to even slight knocks and blood would rise to the surface over a period of weeks or months before erupting through the skins surface.
A full thickness layer of skin would then detach leaving an open wound which took months to heal. Several times in the past the skin damage was so bad the patient had to be treated at hospital.
A decision was made to treat the toe and the skin of both legs from below the knee to the tips of the toes with DHAA Vitamin C serum.
Photo below shows the leg after a slight knock around eight months prior to treatment with DHAA.
Bruised vitamin c deficient leg
It had improved somewhat before the DHAA Vitamin C Serum treatment was started, but it still had several open and encrusted areas of concern and capiiiary leakage/contusion. Photo below shows legs after six weeks treatment with the serum. Overall skin colour and skin thickness have improved but the biggest change is in how the scabs are resolving.
legs treated with vitamin c DHAA serum
The two darkest lesions on the right leg are months old and would normally shed completely leaving an open wound. Now they are healing in from the edges with new pink skin visible underneath. Capillary integrity is already showing signs of improvement as new bruises are not spreading as much or for as long and are starting to resolve without breaking the surface.
Photo Below. Three weeks later and the skin condition and vitality is vastly improved. The lady also had a bad fall a couple of weeks earlier which required hospitalization, the caregivers were concerned that very serious bruises would erupt through the skin again as a consequence. However, after ten weeks of daily application of half a teaspoon of DHAA Vitamin C Serum she had a completely normal bruising response. Deep bruising was evident after the accident but the capillary leakage stopped quickly and the bruising subsided within two weeks.
after vitamin C serum treatment
After treatment with DHAA vitamin C serum
Scientific Research Paper Vitamin C Revisited excerpt below, to view full paper click link at the end:
Abridged: "The role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure. Vitamin C can additionally restore vascular responsiveness to vasoconstrictors, preserve endothelial barrier by maintaining cyclic guanylate phosphatase and occludin phosphorylation and preventing apoptosis. Finally, high-dose vitamin C can augment antibacterial defense. These protective effects against overwhelming oxidative stress due to ischemia/reperfusion, sepsis or burn seems to mitigate organ injury and dysfunction, and promote recovery after cardiac revascularization and in critically ill patients." Full Research Paper here: