SVCT1 and SVCT2： 摄取维生素C的关键蛋白

SVCT1 and SVCT2: key proteins for vitamin C uptake

　

　

维生素C通过两种类型的蛋白质在哺乳动物细胞中积累：钠离子依赖的维生素C转运蛋白（SVCT）和己糖转运蛋白（GLUT）;特别是，SVCT积极进口抗坏血酸，这种维生素的还原形式。 SVCT是由两种不同基因编码的表面糖蛋白，结构非常相似。它们显示出明显的组织分布和功能特征，表明不同的生理作用。 SVCT1参与维生素C的全身稳态，而SVCT2保护代谢活性细胞免受氧化应激。 mRNA或蛋白质水平的调节可用于在需要的位置优先积累抗坏血酸。本综述将总结目前关于SVCT转运蛋白的结构，功能和调节的知识。了解SVCT1和SVCT2的生理作用可能导致开发新的治疗策略以控制细胞内维生素C含量或促进维生素C-药物缀合物的组织特异性递送。

SVCT1 and SVCT2: key proteins for vitamin C uptake

Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import ascorbate, the reduced form of this vitamin. SVCTs are surface glycoproteins encoded by two different genes, very similar in structure. They show distinct tissue distribution and functional characteristics, which indicate different physiological roles. SVCT1 is involved in whole-body homeostasis of vitamin C, while SVCT2 protects metabolically active cells against oxidative stress. Regulation at mRNA or protein level may serve for preferential accumulation of ascorbic acid at sites where it is needed. This review will summarize the present knowledge on structure, function and regulation of the SVCT transporters. Understanding the physiological role of SVCT1 and SVCT2 may lead to develop new therapeutic strategies to control intracellular vitamin C content or to promote tissue-specific delivery of vitamin C-drug conjugates.

 

https://www.researchgate.net/publication/6293873_SVCT1_and_SVCT2_key_proteins_for_vitamin_C_uptake