饮食的脂肪影响关节软骨的健康-关节软骨损伤越严重,脂质沉积越多

The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage

 

 

 

关节软骨是为数不多的具有大量脂质沉积的身体组织之一。脂滴是由软骨细胞和单个脂肪酸自然累积而成的,它对退化性关节疾病动物模型的软骨退化具有保护作用和有害作用。为了更好地评估脂质在人类关节病理学中的作用,对骨关节炎关节软骨的小段进行了脂肪酸的比较分析。

 

 

 

 

用软骨细胞合成活动和疾病严重程度的组织学测定来评估这些数据。正常和骨关节炎标本中个别脂肪酸的分布情况保持不变,有棕榈酸、油酸和亚油酸,占总脂肪酸的85%

 

与此相反,总脂肪酸的水平随着病变程度的增加而显著增加。与正常年龄的关节组织相比,01级轻度病变的总脂肪酸、必需脂肪酸和软骨细胞合成活性分别升高了80%312%393%。更严重的组织参与(6级至9),与更大的增长分别为440%1,100%1150%

 

 

任何组织的胆固醇含量都没有变化。

 

花生四烯酸的积累量大于总脂肪酸含量的比例增加,主要分布在中性脂质分数中,在中度损伤程度的组织中,它几乎占到脂肪酸水平的62%。总体上脂质沉积尤其是花生四烯酸与组织学严重性呈相关性。这种关联提示脂质参与软骨细胞对退行性关节疾病的发展或进展的反应。

 

 

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参考文献

人类骨关节炎的关节软骨脂质异常和组织病理学的严重程度的关联性

The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage☆

 

Articular cartilage is one of very few body tissues uniquely characterized as having substantial stores of lipid deposits. Lipid droplets are naturally accumulated by chondrocytes and individual fatty acids have been shown to have protective as well as deleterious effects on cartilage degradation in animal models of degenerative joint disease. As a means to better assess the role of lipids in human joint pathology, a comparative analysis of fatty acids was undertaken in small segments of osteoarthritic articular cartilage. The data were assessed in terms of chondrocyte synthetic activity and histological determination of disease severity. The distribution profile of individual fatty acids in normal and osteoarthritic specimens remained constant, with palmitic, oleic, and linoleic acids representing 85% of the total fatty acids. In contrast, levels of total fatty acids were markedly increased in association with increasing degree of lesion severity. Compared with tissue from normal-aged joints, grade 0 to 1 mild lesions had elevated levels of total fatty acids, essential fatty acids, and chondrocyte synthetic activity of 80%, 312%, and 393%, respectively. More severe tissue involvement (grade 6 to 9), was associated with even greater increases of 440%, 1,100%, and 1,150%, respectively. No change was noted in cholesterol content in any tissue. The accumulation of arachidonic acid was greater than the proportional increase in total fatty acid content and was primarily distributed into the neutral lipid fraction, where it constituted almost 62% of the fatty acid level in tissues of moderate lesion severity. There was an association of lipid accumulation in general and arachidonic acid in particular with histological severity. This association is suggestive of a lipid involvement in the chondrocyte's response to development or progression of degenerative joint disease.

 

https://www.sciencedirect.com/science/article/pii/002604959190046Y