阳光是最好的药物系列-维生素D
维生素D是一种激素，不是维生素
就在几年前，维生素D被简称为“骨骼维生素”。“多亏了许多科学家的努力,尤其是维生素D的先驱研究者Michael Holick医学博士的发现，体内几乎每一个组织和细胞类型都有维生素D受体，这一发现的结果提示, 需要更高剂量以优化身体的机能。这一发现彻底改变了我们对维生素D在体内的作用的认识。
除非你的身体处于最佳状态，否则你会打开一扇门，通往一系列的疾病，从心脏病和阿尔茨海默病到虚弱的骨骼和糖尿病。
事实上，即使你今天血糖正常，维生素D缺乏也会使你患上胰岛素抵抗，或“糖尿病前期”的可能性增加91%，而且它会使你的患病风险增加一倍以上，从而患上II型糖尿病。
不幸的是，维生素D缺乏是一种全球性的流行病。估计有10亿人没有足够的维生素D水平。有64%的美国人没有足够的维生素D来维持他们所有的组织运行中最佳的状态。
这种缺陷的结果是灾难性的。现在的研究表明，维生素D缺乏症会增加一长串疾病的风险。事实上，低水平的维生素D会增加患非阿尔茨海默氏症的风险，几乎是20倍!
德国研究人员的一项研究发现，维生素D可以使你的免疫功能增加3 - 5倍，同时显著刺激有效的抗微生物肽的产生。
此外，太阳紫外线照射可以刺激皮肤中的维生素D的产生，它已经被证明可以降低病毒呼吸道感染的发病率，以及其它健康状况。
为什么维生素D比任何疫苗都好，并且能提高你的免疫系统3-5倍?
你可能会惊奇地发现，维生素D对你的健康非常重要，尤其是当你仍然觉得它是你骨骼的营养物质的时候。大多数人还认为维生素D确实是一种维生素，但实际上，维生素D的活性形式是体内最有效的激素之一，它比其他任何激素都能调节更多的基因和身体功能。维生素D是在阳光照射后的皮肤中产生的一种促激素，然后转化为强效荷尔蒙。
《D*行动研究》(the D*Action study)的发表的一项研究显示，成年人平均每天需要服用8000个IU的维生素D，以提高其高于40 ng/ml的水平，他们认为这是疾病预防的绝对最低限度。
我们的身体有制造维生素D的能力
当你裸露的皮肤暴露在阳光下时，你的身体就会得到它所需要的维生素D。太阳光线中重要的部分是紫外线B (UVB)。这是获得维生素D最自然的方法。
当你把你的身体暴露在夏天的阳光下时，你的皮肤就会产生大量的维生素D3。这很快就会发生; 令你的皮肤产生烧灼感一半的时间就开始制造维生素D。对于一个皮肤白皙的人来说，这可能需要15分钟的时间，但对于一个皮肤黝黑的人来说，这可能需要几个小时甚至更长时间。
你不需要晒黑或灼伤皮肤来获得你需要的维生素D。短时间暴露你的皮肤会使你的身体在一天内产生所有的维生素D。事实上，在你的皮肤觉得烧灼感的时候，你的身体在很短的时间内就能产生10000到25,000单位的维生素D。当你暴露大面积皮肤时，比如背部，而不是像脸部或手臂这样的小区域，你就能获得最多的维生素D。
The Wonderful Healing Power of Sunlight Series-Vitamin D
Vitamin D is a Hormone -- Not a Vitamin
Just a few years ago, vitamin D was simply known as the “bone vitamin.” Thanks to the hard work of many scientists, especially Michael Holick, MD, a pioneer in vitamin D research, the data show that nearly every tissue and cell type in the body has receptors for vitamin D.1 As a result of this discovery, much higher doses are required for optimal functioning. This discovery has radically changed how we understand the role of vitamin D in the body.
Unless your body is at optimal levels, you are opening the door to a host of disorders, ranging from heart disease and Alzheimer’s to weak bones and diabetes.2,3
In fact, even if you have normal blood sugar today, a vitamin D deficiency makes you 91% more likely to progress to insulin resistance, or “pre-diabetes,” and it more than doubles your risk for progressing to active, type II diabetes.4
Unfortunately, vitamin D deficiency is a global epidemic. An estimated 1 billion people do not have adequate vitamin D levels.5 And 64% of Americans don’t have enough vitamin D to keep all of their tissues operating at peak capacity.6
The results of this deficiency are catastrophic. Studies have now shown that vitamin D deficiency is associated with increased risk of a long list of diseases that span all systems in the body. In fact, low levels of vitamin D increase the risk of non-Alzheimer’s dementia almost 20 times! 7
a study by German researchers found that vitamin D increases your immune function by a factor of 3 to 5, while dramatically stimulating the production of potent anti-microbial peptides.
Furthermore, ultraviolet radiation exposure from the sun, which stimulates the production of vitamin D in your skin, has been shown to reduce the incidence of viral respiratory infections, along with a wide range other health conditions.
Why Vitamin D Is Better than ANY Vaccine and Improves Your Immune System by 3-5 Times
You may find it surprising that vitamin D is so important for your health, especially if you’re still under the impression that it’s mostly a nutrient for your bones. Most people also think that vitamin D is really a vitamin, but in reality, the active form of vitamin D is one of the most potent hormones in your body, and regulates more genes and bodily functions than any other hormone yet discovered. Vitamin D is produced as a pro-hormone in your skin after sunlight exposure, and is then converted to the potent hormone form.
Research published by Grassroots Health from the D*Action study shows the average adult needs to take 8,000 IU's of vitamin D per day in order to elevate their levels above 40 ng/ml, which they believe is the absolute minimum for disease prevention.
Human skin can make large amounts of vitamin D when lots of skin is exposed and the sun is high in the sky.
Your body is designed to get the vitamin D it needs by producing it when your bare skin is exposed to sunlight. The part of the sun’s rays that is important is ultraviolet B (UVB). This is the most natural way to get vitamin D.
Large amounts of vitamin D3 (cholecalciferol) are made in your skin when you expose all of your body to summer sun. This happens very quickly; around half the time it takes for your skin to begin to burn. This could be just 15 minutes for a very fair skinned person, yet a couple of hours or more for a dark skinned person.
You don’t need to tan or to burn your skin in order to get the vitamin D you need. Exposing your skin for a short time will make all the vitamin D your body can produce in one day. In fact, your body can produce 10,000 to 25,000 IU of vitamin D in just a little under the time it takes for your skin to begin to burn. You make the most vitamin D when you expose a large area of your skin, such as your back, rather than a small area such as your face or arms.
https://www.vitamindcouncil.org/about-vitamin-d/how-do-i-get-the-vitamin-d-my-body-needs/
Journal of Molecular and Cellular Cardiology
Volume 98, September 2016, Pages 1-10
Journal of Molecular and Cellular Cardiology
Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation
Author links open overlay panelChristopher J.PelhamElizabeth M.DrewsDevendra K.Agrawal
https://doi.org/10.1016/j.yjmcc.2016.06.067Get rights and content
Highlights
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Perivascular fat elicits anti-contractile effects in mouse mesenteric artery.
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Vitamin D deficiency activates hypoxia signaling in mesenteric perivascular fat.
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Hypoxia induces inflammation and impairs perivascular adipose function.
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Vitamin D supplementation protects against hypoxia-induced vascular dysfunction.
Abstract
Vitamin D deficiency in human subjects is associated with hypertension, metabolic syndrome and related risk factors of cardiovascular diseases. Serum 25-hydroxyvitamin D levels correlate inversely with adiposity in obese and lean individuals. Bioactive vitamin D, or calcitriol, exerts anti-inflammatory effects on adipocytes, preadipocytes and macrophages in vitro. We tested the hypothesis that vitamin D deficiency alters the phenotype of perivascular adipose tissue (PVAT) leading to impaired function in resistance artery. To examine the effects of vitamin D and PVAT on vascular reactivity, myograph experiments were performed on arteries, with or without intact PVAT, from mice maintained on vitamin D-deficient, vitamin D-sufficient or vitamin D-supplemented diet. Systolic blood pressure was significantly increased in mice on vitamin D-deficient diet. Importantly, vitamin D deficiency enhanced angiotensin II-induced vasoconstriction and impaired the normal ability of PVAT to suppress contractile responses of the underlying mesenteric resistance artery to angiotensin II and serotonin. Furthermore, vitamin D deficiency caused upregulation of the mRNA expression of tumor necrosis factor-α, hypoxia-inducible factor-1α and its downstream target lysyl oxidase in mesenteric PVAT. Incubation of mesenteric arteries under hypoxic conditions impaired the anti-contractile effects of intact PVAT on those arteries from mice on vitamin D-sufficient diet. Vitamin D supplementation protected arteries against hypoxia-induced impairment of PVAT function. The protective effects of vitamin D against vascular dysfunction, hypertension and cardiovascular diseases may be mediated, at least in part, through regulation of inflammatory and hypoxia signaling pathways in PVAT.
Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S002228281630219X
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