东京大学研究：辅酶q10 是长寿的因素

CoQ10: The Longevity Factor

By Lina Buchanan

你愿意延长9年的预期寿命吗? 这就是对营养辅酶Q10 (CoQ10)的研究所暗示的可能。

CoQ10以其对心脏和血管健康的益处而闻名。通过帮助被称为线粒体的细胞动力机构更有效地燃烧燃料，CoQ10不仅能够保护心脏，而且能够保护你体内的每一个细胞。

这就是为什么科学家越来越关注CoQ10在心血管系统以外的组织中的作用。有证据表明，CoQ10对大脑和神经系统、哮喘和慢性肺病、糖尿病和代谢综合征、眼睛健康，甚至对衰老的免疫系统有保护作用。

最令人兴奋的是，补充CoQ10可以延长原始动物和哺乳动物的寿命，这为类似的人类长寿效应奠定了基础。

辅酶q10延长寿命

根据衰老的线粒体理论，线粒体的氧化损伤是衰老的根源。简单地说，线粒体的氧化损伤越大，个体的寿命越短。

因此，如果我们能让线粒体更清洁高效地燃烧能量，我们就能减缓衰老过程。这不仅意味着寿命更长，而且意味着更健康。

CoQ10是线粒体能量传递系统的重要组成部分。当CoQ10水平下降时，线粒体功能障碍急剧上升，衰老加速。

然而，当CoQ10被添加到生病或衰老的线粒体中时，它们的功能就会反弹。研究表明，当补充CoQ10时，秀丽隐杆线虫类中较老的蠕虫会经历衰老过程的减慢和寿命的延长。

即使没有显示寿命延长的研究也表明，随着CoQ10的补充，年轻的行为和功能会恢复。

然而，这些好处并不仅限于原始无脊椎动物。研究表明，补充CoQ10的老鼠寿命更长。在一个案例中，补充的动物平均寿命增加了11.7%，最大寿命增加了24%。根据目前78.5年的预期寿命计算，这一增长相当于人类延长了9年以上。

然而，补充CoQ10对小鼠的益处不仅仅局限于延长寿命。终生补充CoQ10可减少中年动物的衰老客观指标。

CoQ10似乎通过一组多目标机制来实现这些特殊效果。

现在很明显，CoQ10直接影响参与衰老的多个基因的表达，尤其是那些调节炎症的基因。这种所谓的“表观遗传”效应是科学研究的最前沿，目的是了解诸如营养等环境因素如何影响我们的遗传负荷。

综上所述，CoQ10的抗氧化、抗炎和表观遗传机制结合在一起，为许多身体系统提供了显著的保护，尤其是那些受线粒体衰老影响最严重的系统。

https://s.click.taobao.com/uIoaKNw

CoQ10: The Longevity Factor

January 2013

By Lina Buchanan

Mitochondria

Mitochondria

Would you like to potentially add 9 years to your life expectancy? That's what research on the nutrient coenzyme Q10 (CoQ10) implies is possible.1

CoQ10 is well known for its heart and vascular health benefits.2 By helping the cellular powerhouses known as mitochondria burn fuel more effectively, CoQ10 is able to protect not only the heart but every cell in your body.3

That's why scientists are growing increasingly fascinated with the role of CoQ10 in tissues beyond the cardiovascular system.2 There is evidence for CoQ10's protective effects in the brain and nervous system, in asthma and chronic lung disease, in diabetes and the metabolic syndrome, on ocular health, and even on the aging immune system.

Most excitingly, there's early support for the idea that CoQ10 supplementation can extend the life span of both primitive animals and mammals, laying the groundwork for a similar pro-longevity effect in humans.

CoQ10 Extends Life Span

Healthy Skin

According to the mitochondrial theory of aging, oxidant damage to the mitochondria is at the root of aging itself.4 Simply put, the more oxidative damage to mitochondria, the shorter the life span of the individual.5,6

Therefore, if we can make mitochondria burn energy more cleanly and efficiently, we can decelerate the aging process. That would mean not only longer life, but a healthier one.

CoQ10 is an essential component of the mitochondrial energy transfer system. When CoQ10 levels fall, mitochondrial dysfunction skyrockets, and aging is accelerated.5

However, when CoQ10 is added back to ailing or aging mitochondria, their function rebounds. Studies show that when supplemented with CoQ10, older worms in the species C. elegans experience a slowing down of the aging process and an extended life span.7

Even studies that don't show life span extension demonstrate a return to youthful behaviors and functions in response to CoQ10 supplementation.8

These benefits aren't restricted to primitive invertebrates, however. Research demonstrates that mice supplemented with CoQ10 live longer. In one case, supplemented animals experienced an 11.7% increase in mean life span, and a 24% increase in maximum life span.1 That increase translates into the equivalent of humans gaining over 9 years, based on today's life expectancy of 78.5 years.9

The benefits of CoQ10 supplementation in mice aren't restricted solely to extending the quantity of life, however. Lifelong dietary supplementation with CoQ10 decreased objective measures of aging even in middle-aged animals.10

CoQ10 appears to achieve these exceptional effects through a multi-targeted set of mechanisms.

It is now evident that CoQ10 directly influences the expression of multiple genes involved in aging, especially those regulating inflammation.11-13 This so-called "epigenetic" effect is at the very forefront of scientific attempts to understand how environmental factors such as nutrition influence our genetic load.

Taken all together, CoQ10's antioxidant, anti-inflammatory, and epigenetic mechanisms combine to offer remarkable protection for a host of body systems, especially those hit hardest by mitochondrial aging.

http://www.lifeextension.com/Magazine/2013/1/CoQ10-The-Longevity-Factor/Page-01