Washington University: Proofs: Sugar Feeds Cancer
Researchers at the School of Medicine at Mount Sinai and the Washington University School of Medicine recently published the results of their work which clearly show the dangers of a sugary diet.
Here is the summary of their paper:
The risk of specific cancers increases in patients with metabolic dysfunction, including obesity and diabetes. Here, we use Drosophila [fruit flies] as a model to explore the effects of diet on tumor progression. Feeding Drosophila a diet high in carbohydrates was previously demonstrated to direct metabolic dysfunction, including hyperglycemia, hyperinsulinemia, and insulin resistance. We demonstrate that high dietary sugar also converts Ras/Src-transformed [cancerous] tissue from localized growths to aggressive tumors with emergent metastases. Whereas most tissues displayed insulin resistance, Ras/Src tumors retained insulin pathway sensitivity, increased the ability to import glucose, and resisted apoptosis. High dietary sugar increased canonical Wingless/Wnt pathway activity, which upregulated insulin receptor gene expression to promote insulin sensitivity. The result is a feed-forward circuit that amplified diet-mediated malignant phenotypes within Ras/Src-transformed tumors. By targeting multiple steps in this circuit with rationally applied drug combinations, we demonstrate the potential of combinatorial drug intervention to treat diet-enhanced malignant tumors.
Here’s what all that means in simpler, non-scientist language:
People with diabetes, or who are obese, or have metabolic syndrome (high blood sugars) are well-known to be at greatly increased risk for developing cancer.
Scientists used fruit flies to see the effect of high-sugar diets on cancer.
Feeding the fruit flies a high sugar diet quickly gave them diabetes.
That high sugar diet also caused small cancerous growths to quickly become very large, aggressive and metastatic (spreading) tumors that voraciously consume the sugar and resist normal cell death (or apoptosis).
The high-sugar diet and resulting aggressive cancer growth increases, spiraling out of control: “the bigger it gets the bigger it will get” – as long as the high sugar “fuel” is available.
Finally, the scientists appeal to the drug companies for research money by saying that there might be ways to fix all this with drugs…
Proof: Sugar Feeds Cancer! | HealthBeat News - Part 1 http://healthbeatnews.com/proof-sugar-feeds-cancer/