维生素C杀灭 肿瘤的种子-肿瘤干细胞生长方面的功效是常用药物的10

NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”




来源:英国索尔福德大学University of Salford







索尔福德大学转化医学 迈克尔·P·Lisanti 教授说:“我们一直在关注如何针对癌干细胞的天然物质包括水飞蓟素(Silibinin)和咖啡酸苯酯CAPE-一种蜜蜂提取物,但到目前为止最令人兴奋的是维生素C的作用。








重点研究能量转移,他们测量了7种物质在实验室对癌干细胞系的影响,临床批准的药物stiripentol(用于治疗儿童癫痫症, 3种天然产物——咖啡酸苯酯(CAPE),硅胶和抗坏血酸,以及实验药物,如actinonin, FK866和2 - DG。


他们发现天然的抗生素actinonin和复方FK866是最有效的,天然产物也抑制了CSC的形成,维生素C的效力是2 – DG10倍。


在诺贝尔奖得主莱纳斯·鲍林(Linus Pauling)的研究中,维生素C曾被证明是一种有效的无毒抗癌药物,最近被证明在日本乳腺癌患者中使用,其死亡率降低了25%。然而,它对癌干细胞活动的影响尚未被评估,在这方面,它表现为糖酵解的抑制剂,在线粒体中产生能量,线粒体是细胞的能量工厂







Vitamin C effective in targeting cancer stem cells

Date:March 8, 2017

Source:University of Salford



Researchers have measured the impact on cancer stem cell metabolism of three natural substances, three experimental pharmaceuticals and one clinical drug.


Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug.


Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK.


The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours.


Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: "We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C.


"Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step."


Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).


The Salford team set out to assess the bioenergetics of cancer stem cells -- the processes which allow the cells to live and thrive -- with a view to disrupting their metabolism.


Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products -- caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid -- and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.


While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency.


Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25% on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context, it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the "powerhouse" of the cell.


Dr Gloria Bonuccelli, lead author and another member of the Salford team added: "This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer.


"Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis."


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Materials provided by University of Salford. Note: Content may be edited for style and length.


Journal Reference:


Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. Lisanti. NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”. Oncotarget, 2015; DOI: 10.18632/oncotarget.15400