中国农业大学 维生素B2增强维生素C对癌细胞的杀灭作用

Vitamin B Sensitizes Cancer Cells to Vitamin-C-Induced Cell Death via Modulation of Akt and Bad Phosphorylation.

 

 

 

 

近年来,越来越多的大学和研究机构加入了维生素C抗癌作用和机理的研究,目前已发现维生素C的抗癌机理包括产生过氧化氢、抑制糖酵解、抑制突变的癌基因等。这个由中国农业大学进行的研究发表在20158月的农业食物化学J Agric Food Chem”上 。

 

维生素C(抗坏血酸Ascorbic acid)是一种必需的膳食营养素,具有多种生物功能。最近的研究为其额外的健康益处提供了有希望的证据,包括抗癌活性。维生素B2是另一种必需的膳食营养素,在一些水果、蔬菜或膳食补充剂中经常与维生素C共存。

 

 

 

本研究的目的是确定维生素CB2结合是否能达到协同抗癌活性。采用MDA-MB-231MCF-7A549细胞评价维生素CB2的组合效应。我们发现维生素CB2的结合在所有被测试的细胞系中都导致了协同的细胞死亡诱导。

 

 

进一步的机制研究表明,维生素B2通过抑制AktBAD基因的磷酸化作用使癌细胞对维生素C敏感。

 

 

 

 

我们的研究发现,维生素B2是一种很有前途的增敏剂,可以改善维生素c为基础的癌症化疗和化疗的疗效。

 

 

 

 

 

J Agric Food Chem. 2015 Aug 5;63(30):6739-48. doi: 10.1021/acs.jafc.5b01909. Epub 2015 Jul 24.

Vitamin B Sensitizes Cancer Cells to Vitamin-C-Induced Cell Death via Modulation of Akt and Bad Phosphorylation.

Chen N1, Yin S1, Song X1, Fan L2, Hu H1.

Author information

1

Department of Nutrition and Health, College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing 100083, People's Republic of China.

2

§College of Veterinary Medicine, China Agricultural University, No. 2 Yunamingyuan West Road, Haidian District, Beijing 100193, People's Republic of China.

Abstract

Vitamin C is an essential dietary nutrient that has a variety of biological functions. Recent studies have provided promising evidence for its additional health benefits, including anticancer activity. Vitamin B2, another essential dietary nutrient, often coexists with vitamin C in some fruits, vegetables, or dietary supplements. The objective of the present study is to determine whether the combination of vitamin C and B2 can achieve a synergistic anticancer activity. MDA-MB-231, MCF-7, and A549 cells were employed to evaluate the combinatory effects of vitamin C and B2. We found that the combination of vitamin C and B2 resulted in a synergistic cell death induction in all cell lines tested. Further mechanistic investigations revealed that vitamin B2 sensitized cancer cells to vitamin C through inhibition of Akt and Bad phosphorylation. Our findings identified vitamin B2 as a promising sensitizer for improving the efficacy of vitamin-C-based cancer chemoprevention and chemotherapy.

 

KEYWORDS:

Akt; Bad; cell death; vitamin B2; vitamin C

https://www.ncbi.nlm.nih.gov/pubmed/26165392