生姜具有抗肺癌的特性具有抑制癌细胞的端粒酶和Myc基因的作用-泰国清迈大学的研究发现

Ginger exhibits anti-lung cancer properties.

 

 

翻译:蓝山

 

 

这个由泰国清迈大学进行的研究揭示了生姜抗癌的另一个机理,具有抑制癌细胞的端粒酶和Myc基因的作用抑制癌细胞的端粒酶可以控制癌细胞的无限增殖,而c-Myc是一种调控肿瘤细胞生长和代谢的关键基因。

 

生姜的根茎(Zingiber officinale Roscoe)在传统医学中有很多的疗效,最近的一些文献也表明,姜 (Ginger) 的许多制剂具有抗癌特性。

 

在这里,我们证明了生姜提取物的乙酸乙酯部分可以抑制癌症的两个重要分子靶点的表达,即在A549肺癌细胞中,以时间和浓度依赖性的方式表达的人端粒酶逆转录酶(hTERT)c-Myc基因(一种调控肿瘤细胞生长和肿瘤代谢的关键基因)。经过处理的细胞在端粒酶活性降低,而不是直接抑制端粒酶。hTERT表达的减少与c-Myc表达的减少同时发生,这是hTERT转录因子之一;因此,hTERT表达的减少可能部分是由于c-Myc的减少。

 

由于端粒酶抑制和Myc抑制都是癌症治疗的特异性靶点,生姜提取物在癌症预防和维持治疗中可能是有益的补充剂

 

 

 

参考文献:

 

生姜提取物在A549肺癌细胞中抑制人端粒酶逆转录酶和c-Myc的表达。

研究机构:泰国清迈清迈大学医学院生物化学系。wirote@chiangmai.ac.th

 

Ginger exhibits anti-lung cancer properties.

- GreenMedInfo Summary

Abstract Title:

Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells.

Abstract Source:

J Med Food. 2010 Dec;13(6):1347-54. PMID: 21091248

Abstract Author(s):

Wirote Tuntiwechapikul, Thanachai Taka, Chonnipa Songsomboon, Navakoon Kaewtunjai, Arisa Imsumran, Luksana Makonkawkeyoon, Wilart Pompimon, T Randall Lee

Article Affiliation:

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. wirote@chiangmai.ac.th

Abstract:

The rhizome of ginger (Zingiber officinale Roscoe) has been reputed to have many curative properties in traditional medicine, and recent publications have also shown that many agents in ginger possess anticancer properties. Here we show that the ethyl acetate fraction of ginger extract can inhibit the expression of the two prominent molecular targets of cancer, the human telomerase reverse transcriptase (hTERT) and c-Myc, in A549 lung cancer cells in a time- and concentration-dependent manner.

 

The treated cells exhibited diminished telomerase activity because of reduced protein production rather than direct inhibition of telomerase. The reduction of hTERT expression coincided with the reduction of c-Myc expression, which is one of the hTERT transcription factors; thus, the reduction in hTERT expression might be due in part to the decrease of c-Myc. As both telomerase inhibition and Myc inhibition are cancer-specific targets for cancer therapy, ginger extract might prove to be beneficial as a complementary agent in cancer prevention and maintenance therapy.

Article Published Date : Dec 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Catechols : CK(14) : AC(11), Ginger : CK(775) : AC(207)

Diseases : Lung Cancer : CK(1043) : AC(393)

Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Telomerase Inhibitor : CK(55) : AC(35)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

 

http://www.greenmedinfo.com/article/ginger-exhibits-anti-lung-cancer-properties-0