Aerobic exercise may improve non-alcoholic fatty liver disease



日期: 2011413

来源:美国生理学会 (American Physiological Society)

简介: 一项针对非酒精性脂肪肝的肥胖者的研究表明,每日快走不仅能提高胰岛素敏感性,还能改善肝脏的多不饱和脂质指数,这被认为是肝脏健康的标志






美国克利夫兰诊所(Cleveland Clinic)的研究人员表示,每天在跑步机上跑步一小时,可以通过启动新陈代谢,减缓因糖尿病引起的氧化损伤,从而减缓肥胖人群非酒精性脂肪肝的进展。一项针对15名非酒精性脂肪肝患者的研究发现,每日走路不仅能提高胰岛素敏感性,还能改善肝脏的多不饱和脂质指数(PUI),这被认为是肝脏健康的标志。


克利夫兰诊所勒纳研究所(Lerner research Institute)病理生物学部门的研究员雅各布.M·豪斯(Jacob M. Haus)说,这种改善与激素脂联素(Adiponectin)的增加有关。脂联素会影响身体对胰岛素的反应,因为它具有抗发炎的特性,因而降低了心脏病发作的风险。但肥胖者的脂联素水平通常较低。豪斯将于201149日至13日在华盛顿华盛顿会议中心举行的2011年实验生物学会议上讨论研究小组的发现。






研究人员测量了参与者的身体组成、呼吸、胰岛素敏感度,以及7天计划前后的PUIs。研究人员还对参与者的血糖、胰岛素和脂联素进行了测试,并对参与者进行了口服葡萄糖耐量测试(OGTTs),以测量葡萄糖从血液中清除的速度。在OGTTs期间,研究人员从参与者的血液中分离出单核细胞(Monocytes) (一个圆形细胞核的血细胞)来研究这些细胞是否产生了称为活性氧(ROS)的分子。高水平的ROS会导致组织的氧化损伤。






















Aerobic exercise may improve non-alcoholic fatty liver disease


April 13, 2011


American Physiological Society


A study of obese people with nonalcoholic fatty liver disease revealed that the daily walks not only increase insulin sensitivity, but improve the liver's polyunsaturated lipid index, which is thought to be a marker of liver health.




Walking on a treadmill for one hour a day may slow the progression of nonalcoholic fatty liver disease in obese people with prediabetes by jump-starting their metabolism and slowing the oxidative damage wrought by the condition, say researchers at the Cleveland Clinic. A study of 15 obese people with nonalcoholic fatty liver disease revealed that the daily walks not only increase insulin sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is thought to be a marker of liver health.


The improvements are linked to an increase in the hormone adiponectin, said Jacob M. Haus, PhD, research fellow in the Department of Pathobiology at the Cleveland Clinic's Lerner Research Institute. Adiponectin influences the body's response to insulin and is associated with a reduced risk of heart attack because of its anti-inflammatory properties. But obese people often have low levels of adiponectin. Haus will discuss the team's findings at the Experimental Biology 2011 meeting (EB 2011), being held April 9-13, 2011 at the Walter E. Washington Convention Center in Washington, DC.



The Study


Participants in the study walked on a treadmill at 85% of their maximum heart rate for 1 hour per day for 7 consecutive days. Researchers measured the participants' body composition, respiration, insulin sensitivity, and PUIs before and after the 7-day program. The researchers also tested the participants' plasma glucose, insulin and adiponectin, and they gave the participants oral glucose tolerance tests (OGTTs), which measure how quickly glucose is cleared from the blood. During the OGTTs, the researchers isolated mononuclear cells (blood cells that have a round nucleus) from the participants' blood to study whether these cells were producing molecules called reactive oxygen species (ROS). High levels of ROS can result in oxidative damage to tissue.


"When people have prediabetes, their blood glucose will be high after an OGTT. We know that hyperglycemia causes oxidative stress, so we wanted to look at [the participants'] monocytes before and after the OGTT," says Dr. Haus. He notes that before the participants began the walking program, their ROS spiked after their OGTTs.



Cutting Metabolic Risks


At study's end, the participants' PUIs had increased an average of 84%. They also experienced increased insulin sensitivity, increased adiponectin and a decrease in the production of ROS, even after their OGTTs.


"We were able to correlate changes in adiponectin with PUI and the body's resting energy metabolism," says Dr. Haus. "The latter gives us an indication of whether carbohydrate or fat is being metabolized. After exercise, the participants were burning more fat."


Burning more fat is a positive reaction to exercise, one that can defend against oxidative damage and therefore the damage of fatty liver disease.


"Exercise appears to affect the cumulative metabolic risk factors for the progression of nonalcoholic fatty liver disease," says Dr. Haus. "We like to think of exercise as medicine."


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