11种耐抗生素细菌(ARB)的太阳光芬顿（photo-Fenton disinfection)消毒和消除代表性AR基因。有证据表明，抗生素耐药性并不意味着对氧化处理有耐药性

Solar photo-Fenton disinfection of 11 antibiotic-resistant bacteria (ARB) and elimination of representative AR genes. Evidence that antibiotic resistance does not imply resistance to oxidative treatment

　

　

抗生素耐药性的出现是对人类健康的一大威胁。在这项工作中，我们研究了用太阳光和太阳光芬顿方法消除抗生素耐药菌株(ARB)。因此，我们设计了一个实验方案，将几种有不同药物敏感性和耐药性模式和结构(革兰氏阳性和革兰氏阴性)的菌株(金黄色葡萄球菌、大肠杆菌和肺炎克雷伯菌)置于日光下进行光芬顿氧化处理。我们表明,太阳光和太阳能光芬顿过程（photo-Fenton）能有效地消除水中的ARB，对药物敏感菌株和耐药菌株的太阳光消毒和光芬顿过程所需要的时间是相似的(大多数是是180 - 240和90 - 240 min,分别)。

此外，细菌结构对处理效果无显著影响。观察到与易感菌株相似的再生模式，在任何处理后的水中均未发现具有较高耐药值的细菌。最后，这两个过程都有效地减少了AR基因(ARGs)，尽管太阳光芬顿比太阳光快。

综上所述，太阳光芬顿过程（photo-Fenton）确保了ARB的有效消毒和水中(或废水)ARGs的消除，是保证ARB和ARG在自然界传播受限的潜在手段。

　

Solar photo-Fenton disinfection of 11 antibiotic-resistant bacteria (ARB) and elimination of representative AR genes. Evidence that antibiotic resistance does not imply resistance to oxidative treatment
Water Research ( IF 7.051 ) Pub Date : 2018-06-26 , DOI: 10.1016/j.watres.2018.06.062
Stefanos Giannakis, Truong-Thien Melvin Le, Jose Manuel Entenza, Cesar Pulgarin

The emergence of antibiotic resistance represents a major threat to human health. In this work we investigated the elimination of antibiotic resistant bacteria (ARB) by solar light and solar photo-Fenton processes. As such, we have designed an experimental plan in which several bacterial strains (Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae) possessing different drug-susceptible and -resistant patterns and structures (Gram-positive and Gram-negative) were subjected to solar light and the photo-Fenton oxidative treatment in water.

We showed that both solar light and solar photo-Fenton processes were effective in the elimination of ARB in water and that the time necessary for solar light disinfection and solar photo-Fenton disinfection were similar for antibiotic-susceptible and antibiotic-resistant strains (mostly 180–240 and 90–120 min, respectively).

Moreover, the bacterial structure did not significantly affect the effectiveness of the treatment.

Similar regrowth pattern was observed (compared to the susceptible strain) and no development of bacteria with higher drug-resistance values was found in waters after any treatment. Finally, both processes were effective to reduce AR genes (ARGs), although solar photo-Fenton was more rapid than solar light. In conclusion, the solar photo-Fenton process ensured effective disinfection of ARB and elimination of ARGs in water (or wastewater) and is a potential mean to ensure limitation of ARB and ARG spread in nature.

http://www.x-mol.com/paper/720071