华盛顿大学：青蒿素选择性杀死癌细胞

University of Washington Artemesia Kills Cancer

　

　

 

青蒿素是一种生长在东南地区的植物，罗文（Rowen）博士过去曾用它来治疗肠道寄生虫。它也被认为是一种安全的疟疾治疗方法。当Rowen博士发现华盛顿大学(University of Washington)生物工程学教授亨利•赖(Henry Lai)和纳伦达•辛格(Narenda Singh)表示，这种草药“可能为癌症患者提供一种安全、无毒、廉价的替代药物”。赖博士和他的同事辛格博士发现，它的使用极大地杀死了乳腺癌细胞和白血病细胞，而没有损伤正常的乳腺细胞和白细胞。

 

根据赖博士的说法，它被认为是有效的，因为当青蒿素或它的任何衍生物与铁接触时，就会发生化学反应，生成被化学家称为自由基的带电原子。细胞分裂时需要铁来复制DNA，由于癌症的特点是细胞分裂失控，癌细胞的铁含量比正常细胞高得多。

 

　

Lai所做的是用更多的铁来刺激癌细胞，然后引入青蒿素选择性地杀死它们。Lai提出的理论认为，更严重的癌症，如胰腺癌和急性白血病(其特征是细胞分裂更快，因此铁含量更高)的反应可能会更好。

 

罗文博士还报道了一年前发表在一份大型癌症杂志上的一篇文章，文章显示，在实验室培养的各种癌细胞中，青蒿素具有显著的抗癌活性。对普通化疗药物具有耐药性的癌症对青蒿素没有耐药性。(国际肿瘤学杂志18;Efferth等人2001年的767-773)

　

　

 

与患者合作的医生之一是一名47岁的女性，她患有4期乳腺癌，并转移脊柱。她使用了IPT，高剂量营养治疗，饮食改变，树突细胞疫苗，多步氧疗等等。她的所有症状都消退了，但CT显示没有变化。添加青蒿素衍生物后，得到了更好的结果。

　

 

越南河内的Hoang博士报告说，在400名癌症患者中，有50% - 60%的患者使用青蒿素实现了长期缓解，同时还制定了综合癌症战略。在这些患者中有一名47岁的女性，她因乙型肝炎和腹水(肝功能衰竭导致大量肿胀)而出现晚期肝癌，离死亡只有几天或几周的时间。今天，两年半后，她还活着，而且没有任何疾病的迹象!

 

辛格博士目前正在跟踪许多癌症患者。他说，虽然没有出现缓解或明显治愈，但所有患者都在做出反应，至少已经稳定下来。他在研究中发现没有一种癌症对青蒿素衍生物没有反应。

　

 

黄医生建议治疗两年。癌症可能像疟疾寄生虫一样。如果只剩下一个细胞，它也会复发。因此，就像疟疾一样，尽管寄生虫在几天内就被清除了，但长期的治疗最好能防止复发。

 

这种治疗据说是无毒的，所以你可以继续无限期地服用它而不产生预期的副作用，尽管它取决于你使用的青蒿素的形式。青蒿琥酯有三种常见的衍生物——青蒿琥酯是水溶性的，可能是最活跃的，毒性最小的，但它在人体内的寿命最短。青蒿醚是油或脂溶性的，半衰期最长。它也有最大的毒性(但这与相当高的剂量有关，这是不必要的。它的最大优势是它能穿过血脑屏障到达神经系统的癌症。青蒿素是这种植物的活性母体化合物。它有一个中间半衰期，很安全，也可以通过血脑屏障。前两种是浓缩提纯活性药物青蒿素的半合成衍生物。辛格博士报告说，由于这些不同的性质(基于实验室实验)，将这些形式组合在一起可能是最好的治疗方法。因此，他认为最好的制剂将含有青蒿素和蒿甲醚，每天在床前提供0.5-2毫克/公斤的每一种(从晚餐后的胃中残留的铁)。黄医生每天两次使用500毫克口服青蒿素，效果良好。最好空腹服用，加一些天然脂肪以增强吸收。残留食物中的任何铁元素都可以中和过氧化物。牛奶是为数不多的铁含量很少的食物之一。全脂牛奶、白软干酪或酸奶都含有丰富的脂肪以增加吸收。

 

此外，罗文博士还表示，他在这种疗法中加入了鱼肝油(含有- s和维生素D)和共轭亚油酸(共轭亚油酸)。他说，除了濒临死亡的患者，服用青蒿素或衍生物已经稳定、改善或减轻了他追踪的每一个癌症患者。医学文献似乎也暗示给系统充氧可能使产品有效。另一种选择是使用某些化疗药物(IPT)，通过自由基机制杀死细胞。

 

蒿属植物产品不同于上述衍生物的集中形式。在最好的条件下，原始草本植物中青蒿素(一种活性物质)的最高浓度甚至不会超过0.5%。辛格博士测试了一些产品，发现与纯青蒿素相比，对培养的癌细胞的抗癌活性可能只有10%到20%。过敏研究小组(800-545-9960)分发经独立实验室分析确认的一种高级青蒿素，这是罗文博士推荐的。

 

请注意:罗文博士警告说，这不是一种单一的治疗方法，应该与综合癌症管理策略结合使用，并在综合内科医生或开放的肿瘤学家的帮助下使用。

 

如需更多信息，请致电206-543-1071或hlai@u.washington.edu。

有关生命科学杂志的更多信息，请访问:http://www.elsevier.com/locate/lifescie。

当我们有时间研究时，我们将提供更多关于这种疗法的信息。

 

 

University of Washington Artemesia Kills Cancer

　

 

The following is information from an article called “Chinese Herb Cures Cancer” by Dr. Robert Jay R Rowen in the publication “Second Opinion” – in the May 2002 issue. Call 1-800-728-2288 to order this publication. Artemesia is also known as wormwood if you decide to research it. You can also go to http://www.artemisia.net/activ.htm for more information on this. I believe this report was published in the November 2001 issue of the journal "Life Sciences."

 

Artemesia is a plant that grows in Southeast that Dr. Rowen has used in the past to treat intestinal parasites. It is also considered a safe malaria treatment. When Dr. Rowen discovered a report by Drs. Henry Lai and Narenda Singh, bioengineering professors at the University of Washington, that indicated that the herb "might provide a safe, non-toxic, and inexpensive alternative for cancer patients", he started using it with cancer patients. Dr. Lai and his colleague, Dr. Singh, had found its use dramatically killed breast-cancer cells and leukemia cells while leaving normal breast cells and white blood cells unscathed.

 

According to Lai, it is believed to work because when artemisinin or any of its derivatives comes into contact with iron, a chemical reaction ensues, spawning charged atoms that chemists call free radicals. Cells need iron to replicate DNA when they divide, and since cancer is characterized by out-of-control cell division, cancer cells have much higher iron concentrations than do normal cells. What Lai did was to pump up cancer cells with even more iron and then introduce artemisinin to selectively kill them. Lai theorizes that more aggressive cancers such as pancreatic and acute leukemia — which are characterized by more rapid cell division and thus higher iron concentrations — may respond even better.

 

Dr. Rowen also reported on an article that appeared about a year ago in a major cancer journal demonstrating significant artemisinin anticancer activity in a wide variety of laboratory cultured cancer cells. Cancers resistant to common chemotherapy drugs showed no resistance to artemisinin. (International Journal of Oncology 18; 767-773, 2001 by Efferth, et al.)

 

One of the patient's Dr. Rowen worked with was a 47-year-old female with stage-4 breast cancer with mets to the spine.. She used IPT, high-dose nutritional therapy, dietary changes, dendritic cell vaccine, multi-step oxygen therapy, and more. All of her symptoms regressed, but the CT showed no change. When artemisinin derivatives were added, greater results were obtained.

 

A Dr. Hoang of Hanoi, Vietnam, reports that 50-60 percent of 400 cancer patients have achieved long-term remission utilizing artemisinin together with a comprehensive integrative cancer strategy. Among these patients is a 47 -year-old female who, presented with terminal liver cancer from hepatitis B and abdominal ascites (massive swelling from liver failure) , was just days or weeks from death. Today; two-and-a-half years later, she is alive and well with no signs of any disease! Dr. Singh is currently following many cancer patients. While not reporting remissions or apparent cures, he says all patients are responding and have at least stabilized. He has found no type of cancer unresponsive to artemisinin derivatives in his studies. Dr. Hoang recommends treatment for two years. Cancer could be like the malaria parasite. If just one cell remains, it can find its way back. Thus, as in malaria, although the parasite is cleared in a few days, prolonged treatment best prevents relapse.

 

This treatment is said to be non-toxic, so you can continue taking it indefinitely with no expected side effects, though it does depend on the form of Artemesia one uses. There are three common Artemesia derivatives - Artesunate is water soluble and may be the most active and the least toxic, but it has the shortest life within the body. Artemether is oil or lipid soluble and has the longest half-life. It also has the most toxicity (but this is related to rather high dosages, which are not necessary. Its big advantage is that it can cross the blood-brain barrier to reach cancers in the nervous system. Artemisinin is the active parent compound of the plant. It has an intermediate half-life, is very safe, and also can cross the blood-brain barrier. The first two are slightly altered semi-synthetic derivatives of artemisinin, the concentrated and purified active agent. Dr. Singh reports that a combination of the forms may be the very best treatment due to these different properties (based on a lab experiment). Thus, he feels the best preparation will contain artemisinin and artemether to provide a dose of 0.5-2 mg/Kg of each form once daily before bed (away from any residual iron left in the stomach from the evening meal). Dr. Hoang used 500 mg twice daily of oral artemisinin with good success. The product is best taken on an empty stomach with some natural fat to enhance absorption. Any iron present from residual food may neutralize the peroxides. Milk is one of the few foods with minimal iron. Whole milk, cottage cheese, or yogurt have ample fat to enhance absorption.

 

Additionally, Dr. Rowen stated that he adds cod liver oil (for its omega-S and vitamin D) and conjugated linoleic acid (CLA) to this therapy. He says that, with the exception of patients very near death, taking artemisinin or derivatives have stabilized, improved, or remitted every cancer patient he has followed. Medical literature also seems to suggest that oxygenating the system might make the products effective. Administration of certain chemotherapy agents (IPT), which kill cells through free radical mechanisms, is another option.

 

Artemesia herb products are not the same as the concentrated forms of the derivatives described above. The highest concentration of artemisinin (the active agent) in the raw herb in best of conditions does not even get beyond one-half percent. Dr. Singh tested some products, finding perhaps only 10-20 percent of anti-cancer activity against cultured cancer cells compared to pure artemisinin. Allergy Research Group (800-545-9960) distributes a high-grade artemisinin confirmed by independent lab analysis, so this is the one Dr. Rowen recommended.

 

Please note: Dr. Rowen warns that this is not a singular therapy and should be used in conjunction with a comprehensive cancer management strategy, together with the help of an integrative medicine physician or an open-minded oncologist.

 

For more information, contact Lai at 206-543-1071 or hlai@u.washington.edu.

For more information on the journal Life Sciences, check the Web at: http://www.elsevier.com/locate/lifescie.

 

We will provide additional information on this therapy as we have time to research it.

 

Artemesia - Welcome To Cancer Cure Foundation  http://www.cancure.org/12-links-page/43-artemesia