爱因斯坦医学院 一项新的研究表明，化疗可能使肿瘤扩散，并引发更严重的肿瘤

Chemotherapy could allow cancer to spread, and trigger more aggressive tumours, a new study suggests

 

 

美国研究人员研究了药物对乳腺癌患者的影响，发现药物治疗增加了癌细胞转移到身体其他部位的几率，而这些部位几乎都是致命的。

　

　

 

在英国，每年约有5.5万名女性被诊断出患有乳腺癌，其中1.1万人将死于乳腺癌。

许多人在手术前接受了化疗，但新的研究表明，尽管它在短期内会缩小肿瘤，但它可能会引发癌细胞在体内的扩散。

 

据认为，这种有毒药物开启了体内的一种修复机制，最终使肿瘤生长得更强壮。它还会增加血管上的“通道”数量，使癌症扩散到全身。

　

 

一幅显示血管“门”打开的图片，让肿瘤扩散

乔治·卡拉詹尼斯(GEORGE KARAGIANNIS)的一幅图片显示了血管中打开的“门”，肿瘤可以通过它扩散

 

纽约叶史瓦大学阿尔伯特·爱因斯坦医学院的乔治·卡拉吉亚尼斯博士发现，在20名接受两种常用化疗药物治疗的病人中，门的数量增加了。

 

他还发现，在老鼠身上，乳腺癌化疗增加了循环在身体和肺部的癌细胞数量。

 

Karagiannis博士说，可以在化疗期间对妇女进行监测，以检查癌症是否开始传播，是否有门道出现。

 

他说:“一种方法是在术前进行几次化疗后获得少量的肿瘤组织。”

 

“如果我们观察到标记分数提高了，我们会建议先停止化疗，先进行手术，然后再进行术后化疗。”我们目前正在计划更广泛的试验来解决这个问题。

 

“在这项研究中，我们只调查了化疗诱导的乳腺癌细胞传播。我们目前正在研究其他类型的癌症，看看是否会产生类似的影响。

 

这项研究发表在《科学转化医学》杂志上。

　

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Chemotherapy could allow cancer to spread, and trigger more aggressive tumours, a new study suggests.

 

Researchers in the US studied the impact of drugs on patients with breast cancer and found medication increases the chance of cancer cells migrating to other parts of the body, where they are almost always lethal.

 

Around 55,000 women are diagnosed with breast cancer in Britain every year and 11,000 will die from their illness.

 

Many are given chemotherapy before surgery, but the new research suggests that, although it shrinks tumours in the short term, it could trigger the spread of cancer cells around the body.

 

It is thought the toxic medication switches on a repair mechanism in the body which ultimately allows tumours to grow back stronger. It also increases the number of ‘doorways’ on blood vessels which allow cancer to spread throughout the body.

 

 An image showing 'doorways' opening in blood vessels which allow tumours to spread

An image showing 'doorways' opening in blood vessels which allow tumours to spread  CREDIT: GEORGE KARAGIANNIS

Dr George Karagiannis, of the Albert Einstein College of Medicine of Yeshiva University, New York, found the number of doorways was increased in 20 patients receiving two common chemotherapy drugs.

 

He also discovered that in mice, breast cancer chemotherapy increased the number of cancer cells circulating the body and in the lungs.

 

Dr Karagiannis said women could be monitored during chemotherapy to check if cancer was starting to circulate and doorways were emerging. 

 

“One approach would be to obtain a small amount of tumour tissue after a few doses of preoperative chemotherapy,” he said.

 

“If we observe that the markers scores are increased we would recommend discontinuing chemo and having surgery first, followed by post-operative chemo. We are currently planning more extensive trials to address the issue.

 

“In this study we only investigated chemotherapy-induced cancer cell dissemination in breast cancer. We are currently working on other types of cancer to see if similar effects are elicited.”

 

 The study was published in the journal Science Translational Medicine.

Chemotherapy may spread cancer and trigger more aggressive tumours, warn scientists  https://www.telegraph.co.uk/science/2017/07/05/chemotherapy-may-spread-cancer-trigger-aggressive-tumours-warn/