Photofrin介导的光动力疗法治疗早期喉部恶性肿瘤

Photofrin-mediated photodynamic therapy for treatment of early stage laryngeal malignancies

 

摘要

评估PHOTOFRIN介导的光动力疗法（PDT）治疗不适合常规头颈部治疗的喉部Tis-T1N0M0鳞状细胞癌（SqCCa）的患者疗效。

　

这是一项回顾性研究，对26名患有喉部早期Tis-T1 SqCCa患者进行了PHOTOFRIN介导的PDT治疗的回顾性研究。给门诊患者静脉注射PHOTOFRIN（porfimer-sodium）（剂量2.0mg / kg），然后在48-60小时后通过光纤微透镜表面递送（手术光剂量50-100J / cm 2）在630nm下进行术中光活化。 26名患者中有16名（62％）表现出完全缓解（平均随访40个月）。有10名患者被发现有部分缓解并且复发，观察到2-33个月随后用重复PDT治疗或常规治疗再次治疗。 PHOTOFRIN介导的光动力疗法可用作治疗喉部Tis-T1N0M0肿瘤的主要方式，或用于治疗先前手术和/或放射治疗失败的患者。 PDT允许保持功能和结构以维持或改善声音而没有全身毒性。患者可以进行多次给药和激光再治疗以控制局部疾病。

　

Photofrin-mediated photodynamic therapy for treatment of early stage laryngeal malignancies

　

Abstract

To evaluate the efficacy of PHOTOFRIN-mediated photodynamic therapy (PDT) for the treatment of Tis-T1N0M0 squamous cell carcinoma (SqCCa) of the larynx in patients not amenable to or who failed conventional head and neck treatment. This is a retrospective study of 26 patients with early stage Tis-T1 SqCCa of the larynx treated with PHOTOFRIN-mediated PDT. Intravenous PHOTOFRIN (porfimer-sodium) (dose 2.0 mg/kg) was administered outpatient, followed by intraoperative photoactivation at 630 nm via fiberoptic microlens surface delivery (surgical light dose 50–100 J/cm2) 48–60 h later. As much as 16 out of 26 patients (62%) have demonstrated complete remission (average follow-up 40 months). There were 10 patients who were noted to have partial remission with recurrence observed 2–33 months subsequently retreated with either repeated PDT therapy or conventional therapy. PHOTOFRIN-mediated photodynamic therapy can be used as a primary modality to treat Tis-T1N0M0 tumors of the larynx or for treatment for those who have failed prior surgery and/or radiation therapy. PDT allows for preservation of function and structure to maintain or improve voice with absence of systemic toxicity. Patients may have multiple drug administrations and laser light retreatment for local disease control.

 

Keywords

Photodynamic therapy Larynx Photofrin Head and neck cancer

　

 

Oncology Reviews

December 2010, Volume 4, Issue 4, pp 203–209 | Cite as

Authors

Authors and affiliations

Vanessa Gayl SchweitzerEmail authorMelissa L. Somers

Department of Otolaryngology/Head and Neck SurgeryHenry Ford Medical GroupDetroitUSA

　

Photofrin-mediated photodynamic therapy for treatment of early stage laryngeal malignancies | SpringerLink  https://link.springer.com/article/10.1007/s12156-010-0059-7