爱荷华大学 使用纳米颗粒来靶向 杀死子宫内膜癌

Researchers use nanoparticles to target, kill endometrial cancer

　

　

 

爱荷华大学药学院(University of Iowa College of Pharmacy)的一项新研究表明，带有肿瘤靶向纳米颗粒的药物可以使癌细胞更容易受到化疗毒性的影响，可以用来治疗侵袭性的、通常是致命的子宫内膜癌。

 

研究人员首次将传统的化疗与一种相对较新的抗癌药物相结合，这种药物可以攻击具有化疗耐药性的肿瘤细胞，将两者都加载到微小的纳米颗粒中，并创造出一种极具选择性且致命的癌症治疗方法。这项为期三年的实验室研究结果今天发表在《自然纳米技术》杂志上。

　

 

这种新疗法可能意味着提高每年被诊断出患有II型子宫内膜癌的大约6000名美国妇女的生存率，同时也标志着靶向癌症治疗的发展迈出了重要的一步。化疗是目前癌症治疗中使全身暴露于抗癌药物的标准，而靶向治疗则直接将药物送到肿瘤部位，从而保护组织器官健康，提高药物疗效。

 

“在这项特别的研究中，我们承担了癌症研究中最大的挑战之一，那就是肿瘤靶向研究，”UI药学研究生、该项研究的首席研究员Kareem Ebeid说。“这是第一次，我们能够结合两种不同的肿瘤靶向策略，利用它们来战胜II型子宫内膜癌。我们相信这种疗法也可以用于治疗其他癌症。

 

Researchers use nanoparticles to target, kill endometrial cancer

 

Tumor-targeting nanoparticles loaded with a drug that makes cancer cells more vulnerable to chemotherapy’s toxicity could be used to treat an aggressive and often deadly form of endometrial cancer, according to new research by the University of Iowa College of Pharmacy.

 

For the first time, researchers combined traditional chemotherapy with a relatively new cancer drug that attacks chemo-resistant tumor cells, loaded both into tiny nanoparticles, and created an extremely selective and lethal cancer treatment. Results of the three-year lab study were published today in the journal Nature Nanotechnology.

 

The new treatment could mean improved survival rates for the roughly 6,000 U.S. women diagnosed with type II endometrial cancer every year and also represents an important step in the development of targeted cancer therapies. In contrast to chemotherapy, the current standard in cancer treatment that exposes the entire body to anti-cancer drugs, targeted treatments deliver drugs directly to the tumor site, thereby protecting healthy tissue and organs and enhancing drug efficacy.

 

“In this particular study, we took on one of the biggest challenges in cancer research, which is tumor targeting,” said Kareem Ebeid, a UI pharmacy science graduate student and lead researcher on the study. “And for the first time, we were able to combine two different tumor-targeting strategies and use them to defeat deadly type II endometrial cancer. We believe this treatment could be used to fight other cancers, as well.”

http://www.nanoappsmedical.com/researchers-use-nanoparticles-to-target-kill-endometrial-cancer/