为什么阳光是治疗皮肤感染的最好方法？

健康的皮肤细胞和红细胞受到阳光照射时产生少量的过氧化氢（H2O2）

Healthy skin cells produce small of hydrogen peroxide exposed to sunlight

　

 

生命的所有生命过程都依赖过氧化氢（H2O2）的存在，免疫系统需要过氧化氢（H2O2)来抵御病原体。体内抗感染(称为粒细胞)的白细胞会产生H2O2，作为抵御寄生虫、病毒、细菌和酵母菌等入侵生物的第一道防线。H202的一些生物杀伤活性可以归因于伽玛干扰素(IFNs)。H202的存在刺激了人类自然杀伤细胞（NK细胞）和单核细胞产生的伽玛干扰素。

　

　

 

当皮肤和血管在皮肤暴露在阳光下时产生H2O2，作为信号召唤白细胞向受伤/发炎的部位集结;

　

 

在人体中，过氧化氢主要产生于三个地方: 肺、肠和甲状腺。因为过氧化氢和负责生产其他活性氧分子的蛋白质, 主要出现在肺部和肠道, 研究者推测与这些发现相关的人类疾病包括涉及白细胞异常水平的肺和肠道疾病如哮喘、慢性阻塞性肺病和某些炎症性肠道疾病。

 

皮肤暴露在紫外光下、通过光氧化产生过氧化氢的研究将，已经进行20多年。Setlow和Timmons等人进行了一项具有里程碑意义的研究，该研究表明，当暴露在光线下时，人体皮肤细胞迅速产生过氧化氢，并研究导致光氧化的紫外光的波长。

　

 

德克萨斯大学MD安德森癌症中心发表了一项名为“鼻黏膜的分子反应，以治疗暴露于宽波段紫外线辐射”的研究。在他们的研究中，他们将人体和呼吸道或鼻组织暴露在紫外线下。

 

他们的研究结论是:“呼吸道上皮细胞的反应与人类表皮的反应非常相似”。换句话说，你的鼻子、喉咙和耳朵的皮肤和你手臂上的皮肤是一样的，对紫外线也有同样的抵抗和反应。

 

 

All of life's vital processes depend upon the presence of H2O2, and H2O2 is required in order for the immune system to defend the body against pathogens. The white blood cells in the body that fight infection (known as granulocytes) produce H2O2 as a first line of defense against invading organisms like parasites, viruses, bacteria and yeast. Some of the biological killing activity of H202 can be attributed to gamma interferon (IFNs). The production of gamma interferon by human natural killer cells and monocytes, is stimulated by the presence of H202

 

Health skin cells and red blood cell produce small amount of H2O2

 

When skin and blood vessel in the dermis are exposed to sunlight, H2O2 is produces, work as  a signal to summons white blood cells to the injured/inflamed site;

 

 in the human body, hydrogen peroxide is produced primarily in three places: lung, gut, and thyroid gland. Because hydrogen peroxide, and the proteins responsible for producing other ROS molecules, are especially present in lung and gut, the researchers hypothesize that human diseases relevant to these findings would include any in the lung and gut that involve disproportionate levels of white blood cells, like asthma, chronic pulmonary obstruction, and some inflammatory gut diseases.

 

The production of hydrogen peroxide from the skin's exposure to UV light, photo-oxidation, has been studied for over 20 years.  A landmark study was done by Setlow and Timmons et al  demonstrates the rapid production of hydrogen peroxide of human skin cells when exposed to light and studies the wavelengths of UV light that cause photo-oxidation. 

The University of Texas MD Anderson Cancer Center published a study entitled, "Molecular response of nasal mucosa to therapeutic exposure to broad-band ultraviolet radiation". In their study they exposed both human subjects and EpiAirway or nasal tissues to UV light. Their study concluded,"Response of respiratory epithelia is very similar to that of the human epidermis". In other words, the skin in your nose, throat, and ear is the same as the skin on your arms and has the same resistance and response to UV light. An additional study done by Iwai showed minimal disturbance of the epidermis at 5 J/cm^2. The suggested daily UV-Aid dosage is 0.3 J/cm^2 equivalent to less than one second of sun exposure.