Main Difference – Agglutination vs Coagulation
Both agglutination and coagulation refer to the formation of a solid mass inside a solution. These processes occur when small particles are massing together. There are many applications of agglutination and coagulation, specifically in the field of biology. The term agglutination is used in the formation of antibody-antigen complexes. The term coagulation is used wherever a clump is formed. Hence, these two terms differ from each other slightly. The main difference between agglutination and coagulation is that agglutination means the small particles coming together whereas coagulation means the formation of a clump.
What is Agglutination
Agglutination is the aggregation of particles to form a single large solid mass. This mass will either stay as a suspension or will sink to the bottom of the container. The end product is called the aggregate. Agglutination occurs with particles which are already present in the solution.
The best example for agglutination comes from biology, in the formation of visible aggregates of antibody-antigen complexes. This is very important in blood grouping because the matching blood group should be given to a person in blood transfusions. If the wrong blood group is given, it will cause the formation of aggregates of red blood cells since antibodies react with the blood cells, forming clumps.
Haemagglutination is the process of aggregation of red blood cells. It is a specific form of agglutination where red blood cells undergo agglutination. It is used in blood typing and for the quantification of the virus.
Agglutination has many applications in the field of science. A major application of agglutination is to detect pathogens and their toxins. Antibody molecules are multivalent substances; this means, several antigens can bind with an antibody. Therefore, large clumps are formed from antigen-antibody agglutination. Toxins formed by pathogens act as antigens. Hence, we can use a suitable antibody to detect these antigens via agglutination.
Difference Between Agglutination and Coagulation | Definition, Characteristics, Applications