Interleukin-2 in the development and control of inflammatory disease.

Hoyer KK1, Dooms H, Barron L, Abbas AK.

Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA.

 

Immunol Rev. 2008 Dec;226:19-28. doi: 10.1111/j.1600-065X.2008.00697.x.

 

Abstract

Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

 

PMID: 19161413 DOI: 10.1111/j.1600-065X.2008.00697.x

[Indexed for MEDLINE]

Interleukin-2 in the development and control of inflammatory disease. - PubMed - NCBI  https://www.ncbi.nlm.nih.gov/pubmed/19161413