甘露糖代谢（糖酵解）对于Th1细胞分化和IFN-γ产生是必需的

Mannose Metabolism(Glycolysis ) Is Essential for Th1 Cell Differentiation and IFN-γ Production

　

 

 

摘要

 

葡萄糖衍生的甘露糖是糖蛋白的常见组分，其缺乏导致蛋白质糖基化的严重缺陷和基本细胞功能的失调。

 

在这项工作中，我们表明甘露糖代谢是小鼠Th1细胞产生IFN-γ必不可少的。此外，我们证明Th1细胞对糖酵解限制的易感性取决于活化条件，并且在降低的糖酵解通量下，甘露糖可用性成为IFN-γ表达的限制因素。

 

本研究揭示了葡萄糖代谢在Th1细胞分化过程中的新作用，为糖酵解在免疫细胞功能中的重要性提供了机制解释。

　

Mannose Metabolism(Glycolysis ) Is Essential for Th1 Cell Differentiation and IFN-γ Production

　

　

Abstract

 

Glucose-derived mannose is a common component of glycoproteins, and its deficiency leads to a severe defect in protein glycosylation and failure in basic cell functions.

　

In this work, we show that mannose metabolism is essential for IFN-γ production by mouse Th1 cells. In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN-γ expression.

　

This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions.

　

SOURCE:

　

Beata M. Zygmunt, Agnieszka Węgrzyn, Weronika Gajska, Tetyana Yevsa, Grzegorz Chodaczek and Carlos A. Guzmán

J Immunol July 20, 2018, ji1700042; DOI: https://doi.org/10.4049/jimmunol.1700042

　

Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-γ Production | The Journal of Immunology  http://www.jimmunol.org/content/early/2018/07/19/jimmunol.1700042