细胞膜动力学和脂质化合物诱导细胞凋亡

Cell membrane dynamics and the induction of apoptosis by lipid compounds

 

抽象

为了研究一些作为细胞凋亡诱导剂的脂质化合物诱导细胞凋亡，使用荧光探针芘测量U937细胞的质膜流动性。

在用脂质诱导剂处理细胞后立即观察到膜流动性的增加。我们还发现细胞凋亡的触发因素在治疗后30分钟内被拉出。来自动态光散射实验的数据表明脂质诱导剂溶解形成乳液。在细胞凋亡的早期阶段，脂质诱导剂从乳剂到细胞脂质层的良好控制转移可导致膜动力学的增加，这可能导致细胞凋亡的诱导。版权所有（C）1999欧洲生化学会联合会。

　

Cell membrane dynamics and the induction of apoptosis by lipid compounds

　

Abstract

To investigate the induction of apoptosis by some lipid compounds which are a potent inducer of apoptosis, the plasma membrane fluidity of U937 cells was measured using the fluorescent probe, pyrene. The increase of the membrane fluidity was observed immediately after the treatment of cells with lipid inducers. We also found that the trigger of apoptosis was pulled within 30 min after treatment. Data from the dynamic light scattering experiment indicated that lipid inducers were dissolved to form the emulsion. At the very early stage of apoptosis, possibly, the well-controlled transfer of lipid inducers from the emulsion to the lipid layer of cells can bring about the increase of membrane dynamics which might lead to the induction of apoptosis. Copyright (C) 1999 Federation of European Biochemical Societies.

 

SOURCE:

Keiji Fujimoto, Chizu Iwasaki, Haruma Kawaguchi, Etsuko Yasugi, Mieko Oshima

　

KEIO University

Department of Applied Chemistry

　

Cell membrane dynamics and the induction of apoptosis by lipid compounds — Keio University  https://keio.pure.elsevier.com/en/publications/cell-membrane-dynamics-and-the-induction-of-apoptosis-by-lipid-co