鼻病毒-引起普通感冒的鼻病毒和干扰素

Rhinovirus-the virus that causes cold and interferon

罗纳德·b·特纳，《曼德尔，道格拉斯和贝内特的传染病原理与实践》(第八版)，2015年
干扰素
白细胞干扰素在1973年首次用于预防鼻病毒感染。最初的研究表明干扰素对感染和疾病都有疗效，但由于缺乏现成的干扰素供应，使得对干扰素在鼻病毒感冒中的系统研究推迟，直到1980年代初重组干扰素出现。随后，通过使用预防和治疗设计(Arruda和Hayden对此进行了回顾)，对天然和实验性鼻病毒感染进行了大量研究。这些研究证实干扰素对预防有效，但对治疗无效。使用干扰素预防鼻病毒感染与鼻毒性有关。由于这个原因，也由于这种材料的高昂成本，开发干扰素作为鼻病毒感染预防药物的努力被放弃了。

Rhinovirus
Ronald B. Turner, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015
Interferon
Leukocyte interferon was first used to prevent rhinovirus infection in 1973. This initial effort demonstrated efficacy for both infection and illness, but the lack of a ready supply delayed the systematic study of interferon in rhinovirus colds until recombinant interferon became available in the early 1980s. A large number of studies were subsequently done in both natural and experimental rhinovirus infections by using both prophylactic and treatment designs (reviewed by Arruda and Hayden). These studies established that interferons were effective for prophylaxis but were ineffective for treatment. The use of interferon for prevention of rhinovirus infection was associated with nasal toxicity. For this reason, and because of the prohibitive cost of the material, the effort to develop interferon as a preventive for rhinovirus infection was abandoned.

https://www.sciencedirect.com/topics/medicine-and-dentistry/interferon