Rhinovirus-the virus that causes cold and interferon
Ronald B. Turner, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015
Leukocyte interferon was first used to prevent rhinovirus infection in 1973. This initial effort demonstrated efficacy for both infection and illness, but the lack of a ready supply delayed the systematic study of interferon in rhinovirus colds until recombinant interferon became available in the early 1980s. A large number of studies were subsequently done in both natural and experimental rhinovirus infections by using both prophylactic and treatment designs (reviewed by Arruda and Hayden). These studies established that interferons were effective for prophylaxis but were ineffective for treatment. The use of interferon for prevention of rhinovirus infection was associated with nasal toxicity. For this reason, and because of the prohibitive cost of the material, the effort to develop interferon as a preventive for rhinovirus infection was abandoned.