挪威AKER 大学医院:老年髋部骨折患者血清抗坏血酸水平低与正常水平

Low levels of serum ascorbic acid in elderly patients with hip fracture

 

本研究发现40例髋骨骨折患者血液中的维生素C浓度比正常家居老人的低。骨骼的主要成分是骨胶原,而维生素C是合成健康骨胶原所必需的成分。

 

 

检测40例近期髋部骨折的老年患者血清抗坏血酸(维生素C)浓度,并与102例居家老年人血清抗坏血酸浓度进行比较。

 

 

 

浓度分别为37 +/- 22 mumol l-1和50 +/- 29 mumol l-1 (p<0.01)。在家庭生活条件和对照条件下入院的患者中,可以根据年龄、性别和季节匹配20对。

髋部骨折患者血清抗坏血酸浓度明显降低(34 +/- 19 mumol l-1 vs 54 +/- 30 mumol l-1, p<0.01)。在配对的两组中,对照组的抗坏血酸浓度出现了季节性变化,而髋部骨折患者则没有。

 

维生素C的主要生理作用-作为抗氧化剂 合成胶原蛋白

由于先前的研究已经发现髋关节骨折患者的几种营养因子浓度降低,我们的发现可能表明血清抗坏血酸浓度降低可能是几种髋关节骨折患者普遍营养不足的一部分。

Low levels of serum ascorbic acid in elderly patients with hip fracture.

The serum concentration of ascorbic acid was measured in 40 elderly patients with a recent hip fracture and compared to values measured in 102 home-living elderly. The concentrations were 37 +/- 22 mumol l-1 vs 50 +/- 29 mumol l-1 (p<0.01). Among the patients admitted from home-living conditions and controls, 20 pairs could be matched with respect to age, sex and season for the test. Serum ascorbic acid concentration was significantly lower in the hip fracture patients (34 +/- 19 mumol l-1 vs 54 +/- 30 mumol l-1, p<0.01). In the matched pairs, a seasonal variation in serum ascorbic acid concentration was found in the controls, but not in the hip fracture patients. As previous studies have found decreased concentrations of several nutritional factors in hip fracture patients, our findings might indicate that a reduced serum concentration of ascorbic acid could be a part of a general nutritional insufficiency in several patients with hip fracture.

http://www.greenmedinfo.com/article/low-levels-serum-ascorbic-acid-elderly-patients-hip-fracture