荷兰莱顿大学 骨髓细胞改善心脏功能 Bone Marrow Cells Improve Heart Function

荷兰莱顿大学:骨髓细胞改善心脏功能

 

研究表明注射骨髓细胞可以改善心绞痛症状

2009年5月19日——一项研究表明,将骨髓细胞直接植入缺血心脏可以显著改善心绞痛症状、心脏功能和患者的生活质量。

荷兰莱顿大学:骨髓细胞改善心脏功能

 

荷兰莱顿大学医学中心的医学博士Jan van Ramshorst和他的同事们说,骨髓细胞疗法对慢性心肌缺血患者可能是一种有益的治疗方法,慢性心肌缺血会导致心脏某些区域的血液长期减少。

他们的研究发表在5月20日的《美国医学会杂志》上。

接受骨髓细胞治疗的参与者的心肌血流量和整体心脏功能都有适度的改善

 

研究对象包括50名患者,大多数是64岁左右的男性,他们的症状对常规治疗没有反应。在研究开始时,每个参与者都接受了从髋关节取出骨髓的手术。然后,参与者随机接受8次骨髓细胞注射或直接注射到受影响心肌的安慰剂溶液。

三个月后,评估心脏功能和血流的测试显示,接受骨髓细胞治疗的参与者的心肌血流量和整体心脏功能都有适度的改善。具体来说,心脏的磁共振成像(MRI)显示骨髓细胞治疗可以改善左心室每次收缩时的泵血功能。(这种测量被称为左心室射血分数,简称LVEF)。

此外,接受骨髓细胞注射的患者:

3个月和6个月后,他们在生活质量测试中取得了更好的成绩;

在固定自行车上运动能力的提高;

根据该杂志报道的背景信息,一些研究也观察了骨髓细胞治疗在类似人群中的效果,发现这种治疗是“安全可行的”。其他较小的评估这种治疗对缺血性心脏病患者疗效的研究也有不同的结果。

目前的研究是首个随机、双盲、安慰剂对照试验,目的是将骨髓细胞治疗心绞痛症状和左心室功能的改善与流向心肌的血液“显著改善”联系起来。目前尚不清楚这些改善是否会改善接受治疗的患者的存活率。

Bone Marrow Cells Improve Heart Function

Study Shows Injections of Bone Marrow Cells May Improve Angina Symptoms

By Kelli Miller

FROM THE WEBMD ARCHIVES

May 19, 2009 -- Placing bone marrow cells directly into a heart that is lacking blood flow significantly improves angina symptoms, heart function, and a patient's quality of life, a study shows.

Jan van Ramshorst, MD, of Leiden University Medical Center in the Netherlands, and colleagues say bone marrow cell therapy may be a beneficial treatment for patients with chronic myocardial ischemia, a condition that results in long-term, reduced blood flow to certain areas of the heart.

Their study is published in the May 20 edition of The Journal of the American Medical Association.

The study included 50 patients, mostly men about 64 years old, whose symptoms did not respond to conventional treatments. At the start of the study, each participant underwent a procedure to have bone marrow removed from the hip. Then, the participants randomly received either eight bone marrow cell injections or a placebo solution directly into the affected heart muscle.

Three months later, tests to evaluate heart function and blood flow revealed that the participants who received the bone marrow cells had modest improvements in blood flow to the heart muscle and in overall heart function. Specifically, magnetic resonance imaging (MRI) of the heart showed that bone marrow cell therapy led to improvements in the left ventricle's ability to pump with each contraction. (This measurement is called left ventricular ejection fraction, or LVEF.)

Those who received the bone marrow cell injections also had:

Better scores on quality-of-life tests three and six months later

Improvements in the ability to exercise on a stationary bicycle

A handful of studies have also looked at the effect of bone marrow cell therapy in similar groups of patients and found the therapy to be "safe and feasible," according to background information in the journal report. Other, smaller studies evaluating the effect of this treatment on patients with ischemic heart disease have had varying results.

The current study is the first randomized, double-blind, placebo-controlled trial to link bone marrow cell therapy improvements in angina symptoms and left ventricle function with a "significant improvement" in the flow of blood to the heart muscle. It is not yet clear whether these improvements will translate into better survival for the treated patients.

Bone Marrow Cells Improve Heart Function  https://www.webmd.com/heart-disease/news/20090519/bone-marrow-cells-improve-heart-function