A multicentered study of lysine therapy in Herpes simplex infection
A multicentered study of lysine therapy in Herpes simplex infection.
The proposed mechanism by which lysine
affects the HSV (primarily HSV type 1 or herpes labialis) is by interfering with
the metabolic balance of lysine and arginine. 2 HSV cells synthesize higher
levels of arginine and lower level of lysine;
Thus, lysine can be a valuable weapon in reducing outbreaks and in healing the infection quickly, whereas Arginine can provoke outbreaks and is required by the herpes simplex virus to replicate and cause symptoms.
Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312-1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. Tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine favors arginine. The opposite, preponderance of lysine to arginine, suppresses viral replication and inhibits cytopathogenicity of herpes simplex virus. The codons characterizing herpes simplex DNA apparently specify production of viral capsids at the expense of host cell histones.
A multicentered study of lysine therapy in Herpes simplex infection. - PubMed - NCBI https://www.ncbi.nlm.nih.gov/pubmed/640102