蔬果中的槲皮素的抗血栓形成作用

Quercetin’s Properties Against Thrombosis

槲皮素(Quercetin)是一种天然的黄酮类化合物,存在于多种植物的花、叶、果实中,具有抗炎、抗氧化、清除氧自由基、抗粘附、抗血栓、抗病毒、抗肿瘤、降血糖、降血脂、降低血压以及免疫调节作用。

实验室实验表明槲皮素具有显著的预防血栓形成的能力，并能分散在血管中形成的血栓。血栓(复数为“血栓”)是血小板、纤维蛋白和其他血液因子的聚集，经常引起血管阻塞。

研究人员证实，低浓度的槲皮素，能抑制血流中在胶原蛋白沉积的血栓。研究人员还在一个用于研究血小板与内皮细胞(内壁血管壁)相互作用的模型中测试了槲皮素。当血液流经一段兔主动脉时，含有低浓度的槲皮素，血小板血栓溶解。

研究人员得出结论，槲皮素通过选择性地结合血小板在血管壁上的血栓形成，并通过恢复正常的内皮-衍生松弛因子和前列腺素的合成，发挥其抗血栓作用。

含槲皮素的蔬果包括：苹果皮、莲藕、洋葱、蓝莓、越橘、黑莓、菠菜、豆角、柑橘、青椒、甘蓝等。

Properties Against Thrombosis

Laboratory experiments suggest that quercetin has the remarkable ability to prevent thrombus formation and to disperse thrombi that have already formed in blood vessels. A thrombus (the plural is "thrombi") is an aggregation of platelets, fibrin and other blood factors, frequently causing obstruction of a blood vessel. Researchers demonstrated that a low concentration of quercetin suppressed thrombus deposits on collagen bathed in a stream of blood. The researchers also tested quercetin in a model used to study interactions between platelets and the endothelium (inner blood vessel wall). When the blood flowing over a piece of rabbit aorta contained a low concentration of quercetin, platelet thrombi dissolved. The researchers concluded that quercetin exerts its anti-thrombotic effect by binding selectively to platelet thrombi on blood vessel walls, and by restoring normal synthesis of endothelium-derived relaxing factor and prostacyclin.

Middleton E Jr, et al. Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol 1992 Mar 17;43(6):1167-79.