纽卡斯尔大学发现，通过节食或手术，胰腺脂肪减少一克就可以治愈2型糖尿病

Type 2 diabetes can be cured through weight loss, Newcastle University finds

　

　

---这个研究发现，胰腺脂肪堆积减少1克，就可以逆转2型糖尿病，之前已有研究发现内脏脂肪堆积是导致胰岛素抵抗的原因，也解释了，为什么体重不胖的人也会有糖尿病。

一项新的研究表明，数百万患有2型糖尿病的人只要减肥就能治愈这种疾病。

　

 

纽卡斯尔大学(Newcastle University)的科学家证实，这种疾病是由胰腺中的脂肪堆积造成的，只需胰腺脂肪减少1克，可以逆转这种限制生命的疾病，恢复胰岛素的生产。

英格兰和威尔士有330万人患有2型糖尿病，到目前为止，人们认为2型糖尿病是慢性的。它会导致失明、中风、肾衰竭和截肢。

“对于2型糖尿病患者来说，减肥可以让他们排出胰腺的多余脂肪，使身体功能恢复正常。”

罗伊·泰勒教授，纽卡斯尔大学说。

但是现在纽卡斯尔大学的研究人员已经证明这种疾病是可以逆转的，即使是长期患有这种疾病的肥胖者。

　

 

18名患有2型糖尿病的肥胖患者接受胃束带手术并限制饮食8周后，病情得到了治愈。在试验中，年龄在25岁到65岁之间的患者平均减掉了2.2英石(约为体重的13%)。至关重要的是，他们还从胰腺中减掉了0.6克脂肪，使器官能够分泌正常水平的胰岛素。

该研究小组目前正计划开展一项为期两年的大型研究，研究对象是格拉斯哥大学的200名研究对象，目的是验证研究结果是否能得到复制，减肥效果能否持续两年。

纽卡斯尔大学的罗伊·泰勒教授说:“对于2型糖尿病患者来说，减肥可以让他们排出胰腺的多余脂肪，使身体功能恢复正常。”泰勒教授也在纽卡斯尔医院工作。

因此，如果你问自己需要减掉多少体重才能摆脱糖尿病，答案是1克。但那克需要是来自胰腺的脂肪。目前，我们实现这一目标的唯一途径是通过任何方式限制卡路里，无论是通过 节食还是手术。

“有趣的是，无论你现在的体重是多少，如何减肥，逆转2型糖尿病的关键因素就是从胰腺减掉1克脂肪。”

糖尿病是一个日益严重的健康危机在英国目前成本NHS每年£869 -卫生保健总数的10%。

在英国，2型糖尿病患者约占所有糖尿病患者的90%，在过去10年里，患者人数增加了59.8%，相当于10年前新增的120万成年人。英国糖尿病协会预测，如果目前的趋势继续下去，到2025年将有500万人患有糖尿病，这是饮食不良和缺乏锻炼的后遗症。

这种疾病过去被称为“成年发病”糖尿病，因为它与中老年人有关，但在过去的15年里，它在儿童中被发现，9月，一个3岁的女孩被诊断出患有这种疾病，这是有史以来最年轻的病人。

传统上，2型糖尿病被认为是一种进行性疾病，最初由饮食控制，然后是药片，但最终可能需要注射胰岛素。

这项新研究首次表明，减肥可以治愈病人。

研究人员发现了胰腺脂肪和糖尿病之间的联系，因为一种新的核磁共振扫描技术允许他们精确检测器官中的脂肪沉积水平。研究表明，糖尿病患者的脂肪水平在8周内下降了1.2%。在8周的时间里，患者被要求将每天的卡路里摄入量限制在1200大卡，大约是推荐摄入量的一半。

一组非糖尿病性肥胖患者的胰腺脂肪水平没有变化，这表明胰腺脂肪的增加是特定于2型糖尿病患者的。

格拉斯哥大学(University of Glasgow)代谢医学教授纳维德•萨塔尔(Naveed Sattar)表示:“这是一件大事，因为它表明，体重增加会引发糖尿病，而体重减得足够多的人可以治愈糖尿病，不再需要胰岛素。”

“我们现在需要做的是确保这个减肥是长期可持续发展,这就是为什么我们正在做一个更大的试验,看看人们可以保持体重。显然有些人将很难做到,不会适合所有人。

“但这是个好消息，因为我们现在可以告诉人们，如果他们减肥，他们会变得更好。”更轻也有助于人们身体更活跃，这也有助于减轻体重。

Charities表示，这项研究强调了饮食和糖尿病之间的重要联系。

英国糖尿病研究主任Alasdair Rankin博士说:“这项研究表明，胰腺脂肪含量与2型糖尿病之间存在重要联系。

“它再次强调了保持健康体重对降低患2型糖尿病风险的重要性，同时也强调了减肥的潜力——最好是通过饮食，但如果减肥失败了，也可以通过手术——来逆转2型糖尿病。”

“但是，虽然一克脂肪听起来并不多，你需要减掉很多体重才能减掉胰腺中的少量脂肪。”虽然一些研究已经表明低热量饮食有逆转2型糖尿病的潜力，但我们还不建议他们这么做，任何想这方面问题的人都应该咨询他们的全科医生。

这项研究今天在网上发表在《糖尿病护理》杂志上，同时他还在温哥华举行的世界糖尿病大会上发表了研究结果。

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Type 2 diabetes can be cured through weight loss, Newcastle University finds

Millions of people suffering from Type 2 diabetes could be cured of the disease if they just lost weight, a new study suggests.

Scientists at Newcastle University have shown the disease is caused by fat accumulating in the pancreas and losing less than one gram from the organ can reverse the life-limiting illness and restore insulin production.

Type 2 diabetes affects 3.3 million people in England and Wales and, until now, was thought to be chronic. It can lead to blindness, stroke, kidney failure and limb amputation.

“For people with Type 2 diabetes, losing weight allows them to drain excess fat out of the pancreas and allows function to return to normal”

Professor Roy Taylor, Newcastle University

But now researchers at Newcastle have shown that the disease can be reversed, even in obese people who have had the condition for a long time.

18 obese people with Type 2 diabetes who were given gastric band surgery and put on a restricted diet for eight weeks were cured of their condition. During the trial the patients, aged between 25 and 65, lost an average of 2.2 stone, which was around 13 per cent of their body weight. Crucially they also lost 0.6 grams of fat from their pancreas, allowing the organ to secrete normal levels of insulin.

The team is now planning a larger two year study involving 200 people with Glasgow University to check that the findings can be replicated and weight loss can be sustained for two years.

“For people with Type 2 diabetes, losing weight allows them to drain excess fat out of the pancreas and allows function to return to normal,” said Professor Roy Taylor, of Newcastle University who also works within the Newcastle Hospitals.

“So if you ask how much weight you need to lose to make your diabetes go away, the answer is one gram. But that gram needs to be fat from the pancreas. At present the only way we have to achieve this is by calorie restriction by any means, whether by diet or an operation.

“What is interesting is that regardless of your present body weight and how you lose weight, the critical factor in reversing your Type 2 diabetes is losing that one gram of fat from the pancreas.”

Diabetes is a growing health crisis in Britain which currently costs the NHS £869m a year – 10 per cent of the total NHS drugs bill.

Type 2 accounts for about 90 per cent of all diabetes cases in Britain and the numbers of sufferers have risen by 59.8 per cent in the past decade, equating to an additional 1.2 million adults compared to ten years ago. Diabetes UK predicts that if current trends continue, five million people will have diabetes by 2025, a legacy of poor diets and lack of exercise.

The illness used to be called ‘mature onset’ diabetes because it was associated with the middle-aged and elderly, but in the past 15 years it has been seen in children and in September a three year old girl was diagnosed with the condition, the youngest patient ever seen.

Traditionally, Type 2 diabetes is seen as a progressive condition which is controlled by diet initially then tablets, but which may eventually require insulin injections.

The new study is the first to suggest that keeping weight down can cure patients.

Researchers were able to spot the link between fat in the pancreas and diabetes because of a new MRI scanning technique which allowed them to accurately test levels of fatty deposits in the organ. It showed that fat levels decreased by 1.2 per cent over eight weeks in diabetic patients. During the eight weeks the patients were asked to limit the calorie intake to 1200 kcal a day, around half of recommended levels.

A control group of non-diabetic obese patients saw no change in the level of fat in their pancreas demonstrating that the increase in fat in the pancreas is specific to people who develop Type 2 diabetes.

Naveed Sattar, professor of Metabolic Medicine at the University of Glasgow said: "This is a big deal because it shows that weight gain is triggering diabetes and that people who lose enough weight can be diabetes free and come off insulin.

"What we need to do now is make sure that this weight loss is sustainable in the long term, which is why we are doing a much bigger trial to see if people can keep the weight off. Obviously some people will struggle to do that and it won't be for everyone.

"But this is good news as we can now tell people that if they lose weight they will get better. Being lighter also helps people become more phsically active, which should also help keep the weight off."

Charities said the study highlighted the important link between diet and diabetes.

Dr Alasdair Rankin, Diabetes UK Director of Research, said: “This study suggests an important link between the amount of fat in the pancreas and Type 2 diabetes.

"It highlights once again the importance of being a healthy weight to reduce your risk of Type 2 diabetes, as well as the potential for weight loss – ideally through diet but also, where that fails, through surgery – to reverse Type 2 diabetes.

"But while a gram of fat doesn’t sound like much, you would need to lose a lot of body weight just to lose this small amount of fat in your pancreas. While some research has shown the potential of low calorie diets to reverse Type 2 diabetes, we do not recommend them yet and anyone thinking about this should speak to their GP.”

The research is being published online today in Diabetes Care and simultaneously he is presenting the findings at the World Diabetes Congress in Vancouver.

Type 2 diabetes can be cured through weight loss, Newcastle University finds  https://www.telegraph.co.uk/science/2016/03/14/type-2-diabetes-can-be-cured-through-weight-loss-newcastle-unive/