短暂的运动也能激活长寿基因AMPK

Even brief bouts of exercise activate AMPK

 

 by Vince Giuliano

 

即使是短暂的运动也能激活AMPK2009年发表的《短暂的高强度间歇运动(HIIT)激活AMPKp38 MAPK信号并增加人类骨骼肌中PGC-1alpha的表达》报告

 

 

我们测试了一种假说,即剧烈的间歇性运动(HIIT)会激活与人类骨骼肌线粒体生物合成相关的信号级联反应。

 

 

我们得出的结论是,通过AMPKp38 MAPKPGC-1alpha传递信号可能在一定程度上解释了低容量高强度间歇运动引起的代谢重构,包括线粒体生物合成和葡萄糖和脂肪酸氧化能力的增强。

 

与此主题相关的其他出版物包括2009年关于高强度间歇运动的分子反应的报告“Molecular responses to high-intensity interval exercise.”。

 

 

AMPK and exercise

 

Even brief bouts of exercise activate AMPK.  The 2009 publication Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle reports “We tested the hypothesis that an acute session of intense intermittent cycle exercise would activate signaling cascades linked to mitochondrial biogenesis in human skeletal muscle — We conclude that signaling through AMPK and p38 MAPK to PGC-1alpha may explain in part the metabolic remodeling induced by low-volume intense interval exercise, including mitochondrial biogenesis and an increased capacity for glucose and fatty acid oxidation.”  Among other publications relating to the same theme is the 2009 report Molecular responses to high-intensity interval exercise.

 

 

https://www.ncbi.nlm.nih.gov/pubmed/19112161

http://www.anti-agingfirewalls.com/2010/06/28/ampk-and-longevity/