全生姜提取物能诱导前列腺癌细胞死亡

Benefits of whole ginger extract in prostate cancer

翻译：蓝山

人们对水果和蔬菜的不断增加和经常食用与引人注目的抗癌效果有密切的关系。生姜(Zingiber officinale Roscoe)是世界范围内的食品和饮料中广泛使用的香料，它是多种生物活性酚醛物质的极佳来源，其中包括一些非挥发性的刺激性化合物，如姜醇、帕拉索、shogaols和姜辣素。生姜可以显示抗炎、抗氧化和抗增殖活性，表明它是一种有希望的化学预防药。

在这里，我们展示了整个生姜提取物(GE)对各种前列腺癌细胞发挥了显著的生长抑制和死亡诱导效应。综合研究证实，生姜提取物扰乱细胞周期进程，破坏增殖能力，调节细胞周期和凋亡调控分子，并诱导caspase驱动，线粒体介导的人前列腺癌细胞凋亡。

值得注意的是，每日口服100 mg/kg体重的生姜提取物小鼠，在裸鼠体内的PC-3异种移植物的生长和进展都受到了大约56%的抑制，如肿瘤体积的测量。通过免疫印迹法和免疫组化法测定，用生姜提取物处理的小鼠肿瘤组织显示其增殖指数下降，凋亡广泛。最重要的是，生姜提取物并没有在正常的、快速分裂的组织如肠道和骨髓中产生任何可检测的毒性。据我们所知，这是第一个在体外和体内抗肿瘤活性的报告，用于治疗前列腺癌。

参考文献：

Benefits of whole ginger extract in prostate cancer

Prasanthi Karna,1 Sharmeen Chagani,1 Sushma R. Gundala,1 Padmashree C. G. Rida,1 Ghazia Asif,1 Vibhuti Sharma,1 Meenakshi V. Gupta,2 and Ritu Aneja1,*

Source: Department of Biology, Georgia State University, Atlanta, GA 30303, USA

2West Georgia Hospitals, LaGrange, GA 30240, USA

It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.

Keywords: Ginger extract, Prostate cancer, Apoptosis, Cell cycle, Chemoprevention

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426621/