生姜有抑制肝脏癌变的作用-马来西亚国立大学 研究发现

 

 

生姜是世界上广泛使用的一种香料。据报道，它具有抗氧化和抗癌特性。

 

我们研究了生姜在乙硫氨酸诱导大鼠肝癌发生中的作用。雄性Wistar大鼠分为5组:1组和2组作为对照组，分别获得正常鼠粮和橄榄油。第3组用橄榄油以100 mg/kg体重溶解橄榄油，4组用不含胆碱的饮食和0.1%的乙硫氨酸放在饮用水中(CDE饮食)，5组用CDE饮食+喂养生姜。血液样本取自于0和8周的眼眶窦，用于测定抗氧化酶、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、过氧化氢酶和脂质过氧化产物丙二醛(MDA)。

　

 

在观察肝脏肿瘤形成的8周内，老鼠也被杀死。CDE饮食诱导大鼠肝结节形成，增加SOD活性。然而，在8周的实验中，它对过氧化氢酶、GPx和MDA水平没有影响。用生姜治疗CDE大鼠时，肝肿瘤形成、SOD活性和MDA水平减少，过氧化氢酶活性增加，但GPx活性与CDE组相比没有变化。总之，生姜补充剂通过清除自由基形成和减少脂质过氧化，抑制了肝脏的癌变。

　

　

参考文献：

生姜(Zingiber Officinale)在乙硫氨酸诱导大鼠肝癌发生中的作用

Chemopreventive Efficacy of Ginger (Zingiber Officinale) in Ethionine Induced Rat Hepatocarcinogenesis

 

Article (PDF Available)  in African Journal of Traditional, Complementary and Alternative Medicines 6(1):87-93 · October 2008 with 54 Reads

DOI: 10.4314/ajtcam.v6i1.57078 · Source: PubMed

Cite this publication

 

Yasmin Mohd Yusof

30.38National University of Malaysia

 

Norliza Ahmad

+ 1

 

Srijit Das

41.97Hospital Universiti Kebangsaan Malaysia (HUKM)

 

Noor Azian Morad

24.98Universiti Teknologi Malaysia

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Abstract

Ginger (Zingiber officinale Rosco) is widely used in foods as a spice all around the world. It has been reported to have antioxidant and anticarcinogenic properties. We investigated the effect of ginger in ethionine induced rat hepatocarcinogenesis. Male Wistar rats were divided into 5 groups: group 1 and 2 served as controls and they received normal rat chow and olive oil respectively. Group 3 was fed with ginger oleoresin dissolved in olive oil at 100 mg/kg body wt. Group 4 was fed with choline deficient diet and 0.1% ethionine in drinking water (CDE diet), and group 5 received ginger with CDE diet. Blood samples were taken from the orbital sinus at 0 and 8 weeks of experiment for the determination of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase and lipid peroxidation end product, malondialdehyde (MDA). Rats were also killed at 8 weeks for the observation of liver tumor formation. CDE diet induced the formation of liver nodules in rats and increased SOD activity. However, it had no effect on catalase, GPx and MDA levels when compared to both controls at 8 weeks of experiment. When CDE rats were treated with ginger, the formation of liver tumour, SOD activity and MDA level reduced, catalase activity was increased but no change was observed for GPx activity when compared to CDE group.

　

In conclusion, ginger supplementation suppressed liver carcinogenesis by scavenging the free radical formation, and by reducing lipid peroxidation.

 

Chemopreventive Efficacy of Ginger (Zingiber Officinale) in Ethionine Induced Rat Hepatocarcinogenesis (PDF Download Available). Available from: https://www.researchgate.net/publication/41453843_Chemopreventive_Efficacy_of_Ginger_Zingiber_Officinale_in_Ethionine_Induced_Rat_Hepatocarcinogenesis [accessed Feb 11 2018].