对金刚乙胺敏感和耐药的流感病毒变种的溶血性和神经氨酸酶活性 呈明显的pH依赖性（pH5.0~6.5）

pH-dependent hemolytic and neuraminidase activity of remantadine-sensitive and -resistant variants of influenza virus

　

　

　

对Remantadin 敏感和耐药的流感病毒变种的pH依赖性溶血和神经氨酸酶活性

　

Vopr Virusol. 1983年1月-2月;28(1):30-2。

摘要
通过对Remantadin 敏感的4种甲型流感病毒株CAPV (H7N7)、USSR/090/77 (H1N1)、Ann Arbor (H2N2)和Texas (H3N2)的溶血和神经氨酸酶活性的pH依赖性及其对Remantadin耐药变体的比较研究。

结果表明，原菌株在较窄的pH范围(5.0和5.5)内发生溶血，在相同pH下神经氨酸酶活性最大。
在耐金刚烷胺变体中，溶血和神经氨酸酶活性的最佳pH值比敏感变种高0.5-1.0。

　

Vopr Virusol. 1983 Jan-Feb;28(1):30-2.

[Article in Russian]

Kornilaeva GV, Molibog EV, Bukrinskaia AG.

Abstract

A comparative study of pH-dependence of hemolytic and neuraminidase activities of four remantadin-sensitive influenza A virus strains CAPV (classical avian plague virus) (H7N7), USSR/090/77 (H1N1), Ann Arbor (H2N2), and Texas (H3N2) and their remantadin-resistant variants was carried out.

　

The original strains were shown to produce hemolysis in a narrow pH range (5.0 and 5.5) and to have maximal neuraminidase activity at the same pH values.

　

In remantadin-resistant variants the optimal pH values for hemolytic and neuraminidase activities were higher by 0.5-1.0 than for the sensitive variants.

https://www.ncbi.nlm.nih.gov/pubmed/6845715