Interferons and viral infections
Fensterl V1, Sen GC。
几乎所有类型的细胞在识别到病毒性分子模型时，尤其是细胞质和核内体受体识别到病毒核酸时，都诱导表达I型和III型干扰素。而II型干扰素等细胞因子诱导IL - 12,它的表达局限于T细胞和NK细胞等免疫细胞。
Interferons and viral infections.
Fensterl V1, Sen GC.
Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Interferons represent a family of cytokines, which is of central importance in the innate immune response to virus infections. All interferons act as secreted ligands of specific cell surface receptors, eliciting the transcription of hundreds of interferon-stimulated genes whose protein products have antiviral activity, as well as antimicrobial, antiproliferative/antitumor, and immunomodulatory effects. Expression of type I and III interferons is induced in virtually all cell types upon recognition of viral molecular patterns, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells.
The effectiveness of the interferon system in counteracting viral infections is reflected by the multitude of inhibitors of interferon induction or interferon action that are encoded by many viruses, preventing their eradication and resulting in the continued coexistence of viruses and vertebrates. The unique biological functions of interferons have led to their therapeutic use in the treatment of diseases such as hepatitis, multiple sclerosis, and certain leukemias.
Interferons and viral infections. - PubMed - NCBI https://www.ncbi.nlm.nih.gov/pubmed/19319841