干扰素和病毒感染

Interferons and viral infections

 

 


Fensterl V1, Sen GC。
作者信息
摘要
干扰素代表一个细胞因子家族,在对病毒感染的先天免疫反应中至关重要。所有的干扰素都是特定细胞表面受体的分泌配体,引发数百个干扰素刺激基因的转录,这些基因的蛋白质产物具有抗病毒活性,以及抗菌、抗增殖/抗肿瘤和免疫调节作用。

几乎所有类型的细胞在识别到病毒性分子模型时,尤其是细胞质和核内体受体识别到病毒核酸时,都诱导表达I型和III型干扰素。而II型干扰素等细胞因子诱导IL - 12,它的表达局限于T细胞和NK细胞等免疫细胞。

干扰素系统对抗病毒感染的有效性反映在许多病毒编码的大量干扰素诱导或干扰素作用抑制剂,阻止它们被根除,导致病毒和脊椎动物继续共存。干扰素独特的生物学功能使其在治疗肝炎、多发性硬化和某些白血病等疾病方面得到了应用。

Interferons and viral infections.


Fensterl V1, Sen GC.
Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.


Abstract
Interferons represent a family of cytokines, which is of central importance in the innate immune response to virus infections. All interferons act as secreted ligands of specific cell surface receptors, eliciting the transcription of hundreds of interferon-stimulated genes whose protein products have antiviral activity, as well as antimicrobial, antiproliferative/antitumor, and immunomodulatory effects. Expression of type I and III interferons is induced in virtually all cell types upon recognition of viral molecular patterns, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells.

The effectiveness of the interferon system in counteracting viral infections is reflected by the multitude of inhibitors of interferon induction or interferon action that are encoded by many viruses, preventing their eradication and resulting in the continued coexistence of viruses and vertebrates. The unique biological functions of interferons have led to their therapeutic use in the treatment of diseases such as hepatitis, multiple sclerosis, and certain leukemias.

Interferons and viral infections. - PubMed - NCBI https://www.ncbi.nlm.nih.gov/pubmed/19319841