进化研究发现:尿酸延长人类的寿命

 

尿酸和抗坏血酸:它们在决定哺乳动物的寿命方面可能扮演抗氧化剂的角色。

尿酸盐已被证明是人类血清中的一种主要抗氧化剂,并被假定在保护组织免受氧自由基的毒性作用和确定灵长类动物的寿命方面具有生物学作用。这一可能性已经通过确定22个灵长类动物和17个非灵长类哺乳动物的最大寿命潜力是否与血清和大脑中每个特定代谢率的尿酸浓度呈正相关。这个分析是基于这样一个概念,即组织对氧自由基的保护程度与该组织的氧代谢率成正比。抗坏血酸另一种潜在的重要的抗氧化剂,用于测定哺乳动物的寿命,也用这种方法进行了研究。结果显示,在血清和大脑中,每一特定代谢率的尿酸浓度与最长寿命潜力呈正相关。抗坏血酸无显著相关。这些结果支持了一种假说,即尿酸盐是一种具有生物活性的抗氧化剂,并参与决定灵长类动物的寿命,特别是对人类和类人猿的寿命。在哺乳动物物种中,抗坏血酸盐似乎并没有起到长寿的作用。

尿酸和抗坏血酸,在人体内的有相似的功能。

 

参考文献:

Arch Gerontol Geriatr 1984 Dec;3(4):321-48

Urate and ascorbate: their possible roles as antioxidants in determining longevity of mammalian species.

Cutler RG

Urate has been shown to be a major antioxidant in human serum and was postulated to have a biological role in protecting tissues against the toxic effects of oxygen radicals and in determining the longevity of primates. This possibility has been tested by determining if the maximum lifespan potentials of 22 primate and 17 non-primate mammalian species are positively correlated with the concentration of urate in serum and brain per specific metabolic rate. This analysis is based on the concept that the degree of protection a tissue has against oxygen radicals is proportional to antioxidant concentration per rate of oxygen metabolism of that tissue. Ascorbate, another potentially important antioxidant in determining longevity of mammalian species, was also investigated using this method. The results show a highly significant positive correlation of maximum lifespan potential with the concentration of urate in serum and brain per specific metabolic rate. No significant correlation was found for ascorbate. These results support the hypothesis that urate is biologically active as an antioxidant and is involved in determining the longevity of primate species, particularly for humans and the great apes. Ascorbate appears to have played little or no role as a longevity determinant in mammalian species.

Uric Acid and Ascorbate, Similar Functions in man