姜黄素可以抑制寨卡病毒、艾滋病病毒、疱疹等病毒

Curcumin from Turmeric Inhibits Zika, HIV, Herpes and Other Viruses

By Case Adams, Naturopath

姜黄在阿育吠陀医学中作为一种药用食物已有几千年的历史。我们已经讨论了它减缓癌症生长的能力，帮助预防阿尔茨海默氏症和帕金森症，帮助解决苔藓Panus，减少2型糖尿病。最近，研究证实，姜黄中的主要的药物化合物——姜黄素（Curcumin)——可以阻止寨卡病毒、肝炎、疱疹、基孔肯雅病毒、流感a型、艾滋病毒和HPV的增长。

这些都是严重的病毒。它们共同影响着全世界数亿人。

有些病毒是由蚊子传播的。例如，寨卡病毒和基孔肯雅病毒是由伊蚊传播的。去年，研究人员发现寨卡病毒与小头畸形等出生缺陷有关。寨卡病毒最近从美国南部和中部蔓延到南部各州包括德克萨斯和佛罗里达。
基孔肯雅病毒也在南美洲和中美洲传播。这种病毒会引起关节疼痛、高烧、皮疹，有时甚至死亡。
目前还没有针对寨卡病毒或基孔肯雅病毒的疫苗。也没有真正的治疗方法。

这些病毒的一个问题是病毒细胞被包住了。它们有糖蛋白外壳，使它们更耐用，更不易被人体免疫系统分解。

有什么自然的保护策略吗?
就与蚊子有关的病毒而言，有很多天然的驱蚊剂值得考虑——尤其是如果你生活或旅行到有寨卡病毒、基孔肯雅病毒或其他蚊子传播疾病的地方。

马来亚大学(University Malaya)在2017年的一项研究发现，包括以下部分在内的精油在阻止蚊子叮咬方面与避蚊胺(DEET,N,N-二乙基-3-甲基苯甲酰胺)一样有效。
以下是一些天然驱蚊剂:
•香茅油
•茶树油
•桉叶油
•印楝油
•百里香石油
•肉桂油
•薰衣草油
•大蒜(内部和外部)
•迷迭香油
•丁香油
•蓖麻油
•柑橘油

至于用抗病毒草药对抗这些类型的包膜病毒，我们建议如下:
•Shatterstone草
•凝集素
•百里香
•姜
•Andrographis

姜黄提取物抑制包膜病毒

在这个列表中，我们现在可以添加姜黄作为一种有效的抗病毒草药。研究发现，姜黄的中心提取化合物姜黄素可以阻止寨卡病毒、基孔肯雅病毒和其他包膜病毒的生长。

法国巴斯德研究所的研究人员研究了姜黄素抑制这些病毒的能力。他们发现，姜黄素不仅抑制病毒，而且干扰了病毒继续感染细胞的能力。
姜黄素也以剂量依赖性的方式实现了这一点。这意味着剂量越大，抑制作用越强，反之亦然。这被认为是确定化合物有效性的黄金标准。

此外，研究人员发现姜黄素干扰了病毒与细胞结合的能力。
病毒必须与细胞结合才能感染它。这种结合也有助于病毒传播到身体的其他部位。病毒通常会利用细胞的器官甚至DNA来帮助传播。姜黄的中心化合物姜黄素通过阻断病毒最初与细胞结合的能力来阻断这些细胞。

研究人员证实了他们的发现如下:
“我们观察到，用姜黄素直接治疗这些包膜病毒和水疱性口炎病毒，可以在剂量和时间上降低病毒的传染性。”
水泡性口炎病毒与狂犬病属于同一科。它也是一种包膜病毒，尤其难以阻止其在动物间传播。
研究人员还提到，这项最新的研究增加了姜黄素被发现可以抑制的病毒名单:
“总之，这些结果扩大了对姜黄素敏感的病毒家族，并为姜黄素对这些包膜病毒的影响提供了一种作用机制。”
我们来讨论一下姜黄素抑制的其他一些病毒。

姜黄素抑制肝炎
发表在英国医学杂志《柳叶刀》(Lancet)上的一项研究发现，姜黄素阻止丙肝病毒进入人体肝细胞。这是一个关键问题，因为丙肝感染肝脏和肝细胞。
这项研究发现姜黄素扰乱了病毒细胞的外膜。研究人员说:
“膜流动性实验表明，姜黄素影响HCV包膜的流动性，导致病毒结合和融合能力下降。”
研究人员还得出结论:
“姜黄姜黄素通过影响细胞膜的流动性从而削弱病毒的结合和融合，从而抑制HCV不受基因型的影响而进入原发性人肝细胞。”

以色列特拉维夫Sourasky医学中心胃肠病学和肝病研究所的一项研究研究了姜黄素和乙肝病毒(HBV)，发现姜黄素通过阻止基因表达的复制来抑制乙肝病毒。
以色列研究人员评论道:
“我们建议姜黄素作为HBV感染的宿主靶向治疗，这可能补充目前的病毒特异性治疗。”

姜黄素抑制流感病毒
国立中兴大学台湾微生物与公共卫生研究所研究了姜黄和姜黄素对甲型流感的影响，他们发现姜黄素能抑制这种流感——主要流感病毒之一。
研究人员发现它会干扰病毒的血液凝集活性。这意味着它阻止了病毒与红细胞结合的能力。

姜黄素抑制HIV-1病毒
早在1995年，研究人员就发现姜黄素在某种程度上抑制了HIV病毒。从那以后，数十项研究证实了这种能力。最新的研究还确定姜黄素将在现场预防病毒感染。
加拿大麦克马斯特大学(McMaster University)的研究人员发现，将姜黄素涂抹在生殖器皮肤细胞上，可以防止通过粘膜感染艾滋病毒。
印度国家免疫学研究所的研究人员发现，姜黄素能抑制受感染细胞产生HIV-1，从而防止感染扩散。他们还发现姜黄素能分解与病毒结合的蛋白质，使病毒无法存活。
姜黄素和HIV的临床研究有限。1995年一项针对40名艾滋病患者的研究没有发现病毒载量下降，但患者表示，服用姜黄素8周后，他们感觉更好。此后研究人员发现，姜黄素的影响可能更为微妙，需要更长的时间才能看到病毒载量减少。
与此同时，其他研究也得出结论，姜黄素可以抑制艾滋病毒的感染和复制。

姜黄素抑制疱疹
密歇根州立大学的研究人员对姜黄素和单纯疱疹1进行了研究。他们发现姜黄素通过干扰病毒的早期基因表达来阻断病毒。这种基因表达是病毒在细胞间复制所必需的。研究人员得出结论:
姜黄素是一种具有多种生物学特性的有效化合物。我们已经证明姜黄素显著影响HSV-1 IE基因的表达，从而削弱了病毒启动裂解性感染周期的能力。
麦克马斯特大学的研究人员还发现姜黄素可以阻止单纯疱疹1和单纯疱疹2病毒的传播。研究发现姜黄素可以防止感染的T细胞中疱疹病毒的复制。

人类乳头状瘤病毒
印度Chittaranjan国家癌症研究所的研究调查了287名hvp呈阳性的女性。研究人员将这些女性随机分为四组。一组给予含有姜黄素的阴道基线膏。另一组使用阴道安慰剂乳膏治疗。另一组采用姜黄素阴道胶囊治疗。第四组服用安慰剂胶囊。
研究人员发现，87%接受过基底姜黄素乳膏的女性都没有感染HPV。经姜黄素胶囊治疗的女性HPV清除率为81%。

姜黄素的神秘的特性
如上所述，许多研究已经证实姜黄素能够帮助治疗感染病毒的患者的症状。这增加了姜黄素的其他好处。
姜黄素影响多种疾病的能力一直是临床研究人员的一个谜:
“多年来，对于基础科学家和临床医生来说，单一药物如何具有这些不同的效果一直是个谜。”

姜黄中含有多少姜黄素?
我们应该注意到，以上所有的研究都测试了姜黄素而不是姜黄本身。由姜根(姜黄根)制成的纯姜黄粉只含有少量姜黄素。此外，姜黄也是咖喱粉的一种成分。所以咖喱粉含有更少的姜黄素。
姜黄中含有2% - 4%的姜黄素。约旦哈希姆特大学2006年的一项研究

　

Curcumin from Turmeric Inhibits Zika, HIV, Herpes and Other Viruses

By Case Adams, Naturopath

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Turmeric has been used as a medicinal food for thousands of years in Ayurvedic medicine. We have discussed its ability to slow cancer growth, help prevent Alzheimer’s and Parkinson’s, help resolve Lichen Panus, and reduce type-2 diabetes. More recently, research has confirmed that the central medicinal compound in turmeric – curcumin – blocks the growth of the zika virus, hepatitis, herpes, chikungunya virus, influenza-A, HIV and HPV.

More recently, research has confirmed that the central medicinal compound in turmeric – curcumin – blocks the growth of the zika virus, hepatitis, herpes, chikungunya virus, influenza-A, HIV and HPV.

These are all serious viruses. Collectively, they affect hundreds of millions of people around the world.

Some of these viruses are transmitted by mosquitoes. For example, zika and the chikungunya viruses are transmitted by the Aedes species of mosquito. Last year, researchers found that zika is linked with birth defects such as microcephaly. Zika virus has recently spread from South and Central America into Southern states in the U.S., including Texas and Florida.

The chikungunya virus is also spreading in South and Central America. This virus causes joint pain, high fevers, rashes and sometimes even death.

There are no vaccines for either zika or chikungunya viruses. There are also no real treatments either.

One of the problems with these viruses is due to the viral cell being enveloped. They have glycoprotein shells that make them more durable and difficult to breakdown by the body’s immune system.

Are there any natural strategies for protection?

As far as mosquito-related viruses go, there are a number of natural mosquito repellents to consider - especially if you live or are travelling to a location that has zika or chikungunya or any number of other mosquito-transmitted diseases.

A 2017 study from the University Malaya found that essential oils including some of the below were as effective as DEET (N,N-Diethyl-3-methylbenzamide) in deterring mosquito bites.

Here is a list of natural mosquito repellents:

• Citronella oil

• Tea tree oil

• Eucalyptus oil

• Neem oil

• Thyme oil

• Cinnamon oil

• Lavender oil

• Garlic (internal and external)

• Rosemary oil

• Clove oil

• Castor oil

• Citrus oil

As far as fighting these types of enveloped viruses with antiviral herbs, we suggest the following:

• Shatterstone herb

• Lectins

• Thyme

• Ginger

• Andrographis

Turmeric extract inhibits enveloped viruses

To this list we can now add turmeric as a potent antiviral herb. Research has found that turmeric’s central extracted compound, curcumin, blocks the growth of zika and chikungunya and other enveloped viruses.

Researchers from France’s prestigious Pasteur Institute researched the ability of curcumin to inhibit these viruses. They found that not only does curcumin inhibit the viruses, but it interfered with the virus’ ability to continue infecting cells.

Curcumin also accomplished this in a dose-dependent manner. This means that the larger the dose, the more inhibition was exerted and vice versa. This is considered the gold standard in determining effectiveness of a compound.

Furthermore, the researchers found that curcumin interfered with the virus’ ability to bind to cells.

A virus must bind to a cell in order to infect it. This binding also helps the virus transmit itself to other parts of the body. The virus will often utilise the cell’s organs and even DNA to help it spread. Turmeric’s central compound curcumin blocks these by blocking the virus’ ability to bind to cells in the first place.

The researchers confirmed their findings as follows:

“We observed that the direct treatment of a virus with curcumin reduced infectivity of virus in a dose and time-dependent manner for these enveloped viruses, as well as vesicular stomatitis virus.”
The vesicular stomatitis virus belongs in the same family as rabies. It is also an enveloped virus and it has been particularly hard to prevent its spread among animals.”
The researchers also mentioned that this latest study adds to the list of viruses that curcumin has been found to inhibit:

“Together, these results expand the family of viruses sensitive to curcumin and provide a mechanism of action for curcumin’s effect on these enveloped viruses.”
Let’s discuss some of these other viruses inhibited by curcumin.

Curcumin inhibits hepatitis

A study published in Lancet, the British Journal of Medicine, found that turmeric’s curcumin blocks the entry of hepatitis C virus into human liver cells. This is a critical issue because hepatitis C infects the liver and liver cells.

This study found that curcumin disturbed the outer envelope of the viral cells. The researchers stated:

“Membrane fluidity experiments indicated that curcumin affected the fluidity of the HCV envelope resulting in the impairment of viral binding and fusion.”
The researchers also concluded:

“Turmeric curcumin inhibits HCV entry independently of the genotype and in primary human hepatocytes by affecting membrane fluidity thereby impairing virus binding and fusion.”
A study from Israel’s The Institute of Gastroenterology and Liver Disease at the Tel-Aviv Sourasky Medical Center studied curcumin and the hepatitis B virus found that curcumin inhibits hepatitis B by stopping the replication of gene expression.

The Israeli researchers commented:

“We suggest curcumin as a host-targeted therapy for HBV infection that may complement current virus-specific therapies.”
Curcumin inhibits influenza-A virus

Research from Taiwan’s Graduate Institute of Microbiology and Public Health at the National Chung Hsing University studied turmeric and curcumin on influenza type A. They found that curcumin inhibits this influenza – one of the major flu viruses.

The researchers found that it interferes with the virus’ haemagglutination activity. This means that it blocks the virus’ ability to bind onto red blood cells.

Curcumin inhibits HIV-1 virus

As far back as 1995, researchers discovered that curcumin somehow inhibited the HIV virus. Since then dozens of studies have confirmed this ability. Newer research has also determined that curcumin will prevent the virus’ infection at the site.

Researchers from Canada’s McMaster University found that applying curcumin onto genital skin cells prevented infection from HIV across the mucosal membranes.

Researchers from India’s National Institute of Immunology found that curcumin inhibited HIV-1 production by infected cells – preventing the infection from spreading. They also found that curcumin breaks down a protein that binds with the virus – leaving the virus unable to be viable.

Clinical research on curcumin and HIV is limited. A 1995 study of 40 AIDS patients didn’t find decreased viral loads, but the patients said they felt better after 8 weeks of taking the curcumin. Researchers since have noted that curcumin’s effects may be more subtle and take longer to see reduced viral loads.

Meanwhile, other studies have since concluded curcumin inhibits HIV infection and replication.

Curcumin inhibits herpes

Researchers from Michigan State University studied curcumin and herpes simplex-1. They found that curcumin blocked the virus by interfering in the virus’ early gene expression. This gene expression is required in order for the virus to replicate among cells. The researchers concluded:

“Curcumin is a potent compound with various biological properties. We have shown that curcumin significantly affects HSV-1 IE gene expression which thereby diminishes the ability of the virus to launch the lytic infectious cycle.”
McMaster University researchers also found that curcumin blocked the spread of herpes simplex-1 and herpes simplex-2 viruses. The research found that curcumin prevented replication of the herpes viruses among infected T-cells.

Human papillomavirus

Research from India’s Chittaranjan National Cancer Institute studied 287 women who were HVP-positive. The researchers randomly divided the women into four groups. One group was given vaginal basant cream containing curcumin. Another group was treated with vaginal placebo cream. Another group was treated with curcumin vaginal capsules. The fourth group was given placebo capsules.

The researchers found that 87 percent of the women treated with the basant-curcumin cream were cleared of HPV. The curcumin capsule-treated women experienced a 81 percent HPV clearance rate.

Curcumin’s mysterious nature

As evidenced above, many studies have confirmed that curcumin has the ability to help remediate symptoms among patients infected with viral conditions. This adds to the many other benefits of curcumin.

The ability of curcumin to affect so many conditions has been a mystery among clinical researchers:

“How a single agent can possess these diverse effects has been an enigma over the years, both for basic scientists and clinicians.”

How much curcumin does turmeric contain?

We should note that all of the above research has tested curcumin and not turmeric per se. A pure turmeric powder made from turmeric roots (Curcuma longa) contains only a small fraction of curcumin. Furthermore, turmeric is an ingredient of curry powder. So curry powder will contain even less curcumin.

Turmeric contains about 2 to 4 percent curcumin. A 2006 study from Jordan’s Hashemite University analysed 28 products that were labelled either as turmeric or curry powder.

The researchers found that pure turmeric powder had the highest curcumin content. The average curcumin content among the

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https://www.theartofhealing.com.au/curcumin.html